Fabrication of a dual-drug-loaded smart niosome-g-chitosan polymeric platform for lung cancer treatment

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dc.authoridAtefeh Zarepour / 0000-0002-0347-5840en_US
dc.authoridAli Zarrabi / 0000-0003-0391en_US
dc.authorscopusidAtefeh Zarepour / 56700291100en_US
dc.authorscopusidAli Zarrabi / 23483174100en_US
dc.authorwosidAtefeh Zarepour / DZE-4304-2022en_US
dc.authorwosidAli Zarrabi / U-2602-2019en_US
dc.contributor.authorZarepour, Atefeh
dc.contributor.authorEğil, Abdurrahim Can
dc.contributor.authorCokol Çakmak, Melike
dc.contributor.authorEsmaeili Rad, Monireh
dc.contributor.authorÇetin, Yüksel
dc.contributor.authorAydınlık, Şeyma
dc.contributor.authorZarrabi, Ali
dc.date.accessioned2023-08-31T10:46:38Z
dc.date.available2023-08-31T10:46:38Z
dc.date.issued2023en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractChanges in weather conditions and lifestyle lead to an annual increase in the amount of lung cancer, and therefore it is one of the three most common types of cancer, making it important to find an appropriate treatment method. This research aims to introduce a new smart nano-drug delivery system with antibacterial and anticancer capabilities that could be applied for the treatment of lung cancer. It is composed of a niosomal carrier containing curcumin as an anticancer drug and is coated with a chitosan polymeric shell, alongside Rose Bengal (RB) as a photosensitizer with an antibacterial feature. The characterization results confirmed the successful fabrication of lipid-polymeric carriers with a size of nearly 80 nm and encapsulation efficiency of about 97% and 98% for curcumin and RB, respectively. It had the Korsmeyer-Peppas release pattern model with pH and temperature responsivity so that nearly 60% and 35% of RB and curcumin were released at 37 degrees C and pH 5.5. Moreover, it showed nearly 50% toxicity against lung cancer cells over 72 h and antibacterial activity against Escherichia coli. Accordingly, this nanoformulation could be considered a candidate for the treatment of lung cancer; however, in vivo studies are needed for better confirmation.en_US
dc.identifier.citationZarepour, A., Egil, A. C., Cokol Cakmak, M., Esmaeili Rad, M., Cetin, Y., Aydinlik, S., ... & Zarrabi, A. (2023). Fabrication of a Dual-Drug-Loaded Smart Niosome-g-Chitosan Polymeric Platform for Lung Cancer Treatment. Polymers, 15(2), 298.en_US
dc.identifier.doi10.3390/polym15020298en_US
dc.identifier.issn2073-4360en_US
dc.identifier.issue2en_US
dc.identifier.pmid36679179en_US
dc.identifier.urihttp://dx.doi.org/10.3390/polym15020298
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3960
dc.identifier.volume15en_US
dc.identifier.wosWOS:000916433400001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorZarepour, Atefeh
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofPolymersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNiosomeen_US
dc.subjectRose Bengalen_US
dc.subjectDual Responsive Nanocarrieren_US
dc.subjectAnticanceren_US
dc.subjectAntibacterialen_US
dc.titleFabrication of a dual-drug-loaded smart niosome-g-chitosan polymeric platform for lung cancer treatmenten_US
dc.typeArticleen_US

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