Evaluation of pre- and post-transplant electroencephalographic examination in hematopoietic stem cell transplant patients

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dc.authoridGÜZEY ARAS, Yeşim/0000-0002-2000-8056
dc.authorwosidGÜZEY ARAS, Yeşim/IQS-3080-2023
dc.contributor.authorYavlal, Figen
dc.contributor.authorDogan Gungen, Belma
dc.contributor.authorGuzey Aras, Yesim
dc.contributor.authorCelik, Yusuf
dc.date.accessioned2024-05-19T14:42:13Z
dc.date.available2024-05-19T14:42:13Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBackground and purpose - Haematopoietic stem cell transplantation (HSCT) is one of the most effective treatment methods for many malignant and non-malignant diseases. In this study, we aimed to detect electroencephalographic (EEG) anomalies at an early stage in patients who underwent allogeneic and autologous HSCT and required the management of potentially lifethreatening non-convulsive seizures. Methods - The study was conducted with 53 patients. The age, gender, HSCT type (allogeneic or autologous), and treatment regimens applied before and after HSCT were recorded. All patients underwent EEG monitoring twice, once on the first day of hospitalization and again one week after conditioning regimens began and HSCT was performed. Results - When the pre-transplant EEG findings were examined, 34 (64.2%) patients had normal EEGs and 19 (35.8%) had abnormal EEGs. After transplantation, 27 (50.9%) had normal EEG findings, 16 (30.2%) had a basic activity disorder, 6 (11.3%) had a focal anomaly, and 4 (7.5%) had a generalised anomaly. In the allogeneic group, the anomaly rate in post-transplant EEGs was significantly higher than that in the autologous group (p<0.05). Conclusion - It is important to consider the likelihood of epileptic seizures in the clinical follow-up of HSCT patients. EEG monitoring is crucial for the early diagnosis and treatment of such non-convulsive clinical manifestations.en_US
dc.identifier.doi10.18071/isz.76.0051
dc.identifier.endpage57en_US
dc.identifier.issn0019-1442
dc.identifier.issn2498-6208
dc.identifier.issue1-2en_US
dc.identifier.pmid36892295en_US
dc.identifier.scopus2-s2.0-85150001317en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage51en_US
dc.identifier.urihttps://doi.org10.18071/isz.76.0051
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5215
dc.identifier.volume76en_US
dc.identifier.wosWOS:001080361100007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherLiteratura Medicaen_US
dc.relation.ispartofIdeggyogyaszati Szemle-Clinical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectHaematopoietic Stem Cell Transplantationen_US
dc.subjectConditioning Regimensen_US
dc.subjectEegen_US
dc.subjectEpileptic Anomalyen_US
dc.titleEvaluation of pre- and post-transplant electroencephalographic examination in hematopoietic stem cell transplant patientsen_US
dc.typeArticleen_US

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