Physiological Rhythms and Biological Variation of Biomolecules: The Road to Personalized Laboratory Medicine

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dc.authoridCoskun, Abdurrahman/0000-0002-1273-0604
dc.authoridZarepour, Atefeh/0000-0002-0347-5840
dc.authoridZarrabi, Ali/0000-0003-0391-1769
dc.authorwosidCoskun, Abdurrahman/C-3906-2015
dc.authorwosidZarepour, Atefeh/AAH-9225-2020
dc.authorwosidZarrabi, Ali/U-2602-2019
dc.contributor.authorCoskun, Abdurrahman
dc.contributor.authorZarepour, Atefeh
dc.contributor.authorZarrabi, Ali
dc.date.accessioned2024-05-19T14:39:26Z
dc.date.available2024-05-19T14:39:26Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractThe concentration of biomolecules in living systems shows numerous systematic and random variations. Systematic variations can be classified based on the frequency of variations as ultradian (<24 h), circadian (approximately 24 h), and infradian (>24 h), which are partly predictable. Random biological variations are known as between-subject biological variations that are the variations among the set points of an analyte from different individuals and within-subject biological variation, which is the variation of the analyte around individuals' set points. The random biological variation cannot be predicted but can be estimated using appropriate measurement and statistical procedures. Physiological rhythms and random biological variation of the analytes could be considered the essential elements of predictive, preventive, and particularly personalized laboratory medicine. This systematic review aims to summarize research that have been done about the types of physiological rhythms, biological variations, and their effects on laboratory tests. We have searched the PubMed and Web of Science databases for biological variation and physiological rhythm articles in English without time restrictions with the terms Biological variation, Within-subject biological variation, Between-subject biological variation, Physiological rhythms, Ultradian rhythms, Circadian rhythm, Infradian rhythms. It was concluded that, for effective management of predicting, preventing, and personalizing medicine, which is based on the safe and valid interpretation of patients' laboratory test results, both physiological rhythms and biological variation of the measurands should be considered simultaneously.en_US
dc.identifier.doi10.3390/ijms24076275
dc.identifier.issn1661-6596
dc.identifier.issn1422-0067
dc.identifier.issue7en_US
dc.identifier.pmid37047252en_US
dc.identifier.scopus2-s2.0-85152334486en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org10.3390/ijms24076275
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4778
dc.identifier.volume24en_US
dc.identifier.wosWOS:000969909100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofInternational Journal of Molecular Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectBiological Variationen_US
dc.subjectCircadian Rhythmen_US
dc.subjectInfradian Rhythmsen_US
dc.subjectPhysiological Rhythmsen_US
dc.subjectUltradian Rhythmsen_US
dc.subject3p Medicineen_US
dc.titlePhysiological Rhythms and Biological Variation of Biomolecules: The Road to Personalized Laboratory Medicineen_US
dc.typeReview Articleen_US

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