CRISPR technology: A versatile tool to model, screen, and reverse drug resistance in cancer

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dc.authoridMirian, Mina/0000-0002-9322-2707
dc.authoridTabatabaee, Aliye/0000-0002-9240-7662
dc.authoridCasarcia, Nicolette/0000-0002-6280-7841
dc.authorwosidMirian, Mina/AHA-6980-2022
dc.contributor.authorShirani-Bidabadi, Shiva
dc.contributor.authorTabatabaee, Aliye
dc.contributor.authorTavazohi, Nazita
dc.contributor.authorHariri, Amirali
dc.contributor.authorAref, Amir Reza
dc.contributor.authorZarrabi, Ali
dc.contributor.authorCasarcia, Nicolette
dc.date.accessioned2024-05-19T14:39:48Z
dc.date.available2024-05-19T14:39:48Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBackground: Drug resistance is a serious challenge in cancer treatment that can render chemotherapy a failure. Understanding the mechanisms behind drug resistance and developing novel therapeutic approaches are cardinal steps in overcoming this issue. Clustered regularly interspaced short palindrome repeats (CRISPR) gene-editing technology has proven to be a useful tool to study cancer drug resistance mechanisms and target the responsible genes. In this review, we evaluated original research studies that used the CRISPR tool in three areas related to drug resistance, namely screening resistance-related genes, generating modified models of resistant cells and animals, and removing resistance by genetic manipulation. We reported the targeted genes, study models, and drug groups in these studies. In addition to discussing different applications of CRISPR technology in cancer drug resistance, we analyzed drug resistance mechanisms and provided examples of CRISPR's role in studying them. Although CRISPR is a powerful tool for examining drug resistance and sensitizing resistant cells to chemo-therapy, more studies are required to overcome its disadvantages, such as off-target effects, immunotoxicity, and inefficient delivery of CRISPR/cas9 into the cells.en_US
dc.description.sponsorshipNovel Drug Delivery Systems Research Center, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan [298136]; Vice-presidency for Research of Isfahan University of Medical Sciences, Isfahan [198150]en_US
dc.description.sponsorshipThis work is supported by Novel Drug Delivery Systems Research Center, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan (Grant No. 298136) and Vice-presidency for Research of Isfahan University of Medical Sciences, Isfahan (Grant No. 198150) .en_US
dc.identifier.doi10.1016/j.ejcb.2023.151299
dc.identifier.issn0171-9335
dc.identifier.issn1618-1298
dc.identifier.issue2en_US
dc.identifier.pmid36809688en_US
dc.identifier.scopus2-s2.0-85148338225en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org10.1016/j.ejcb.2023.151299
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4851
dc.identifier.volume102en_US
dc.identifier.wosWOS:000948659100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Gmbhen_US
dc.relation.ispartofEuropean Journal of Cell Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectCanceren_US
dc.subjectDrug Resistanceen_US
dc.subjectCrispr Technologyen_US
dc.subjectCancer Therapyen_US
dc.titleCRISPR technology: A versatile tool to model, screen, and reverse drug resistance in canceren_US
dc.typeArticleen_US

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