A molecular approach to maggot debridement therapy with Lucilia sericata and its excretions/secretions in wound healing

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dc.authoridFatma Kübra Tombultürk / 0000-0002-4358-2309en_US
dc.authorscopusidFatma Kübra Tombultürk / 56748052500
dc.authorwosidFatma Kübra Tombultürk / L-3969-2018
dc.contributor.authorTombultürk, Fatma Kübra
dc.contributor.authorKanigur-Sultuybek, Gonul
dc.date.accessioned2021-08-08T08:20:23Z
dc.date.available2021-08-08T08:20:23Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Laboratuvar Teknikleri Bölümüen_US
dc.description.abstractChronic wounds caused by underlying physiological causes such as diabetic wounds, pressure ulcers, venous leg ulcers and infected wounds affect a significant portion of the population. In order to treat chronic wounds, a strong debridement, removal of necrotic tissue, elimination of infection and stimulation of granulation tissue are required. Maggot debridement therapy (MDT), which is an alternative treatment method based on history, has been used quite widely. MDT is an efficient, simple, cost-effective and reliable biosurgery method using mostly larvae of Lucilia sericata fly species. Larvae can both physically remove necrotic tissue from the wound site and stimulate wound healing by activating molecular processes in the wound area through the enzymes they secrete. The larvae can stimulate wound healing by activating molecular processes in the wound area through enzymes in their excretions/secretions (ES). Studies have shown that ES has antibacterial, antifungal, anti-inflammatory, angiogenic, proliferative, hemostatic and tissue-regenerating effects both in vivo and in vitro. It is suggested that these effects stimulate wound healing and accelerate wound healing by initiating a direct signal cascade with cells in the wound area. However, the enzymes and peptides in ES are mostly still undefined. Examining the molecular content of ES and the biological effects of these ingredients is quite important to illuminate the molecular mechanism underlying MDT. More importantly, ES has the potential to have positive effects on wound healing and to be used more as a therapeutic agent in the future, so it can be applied as an alternative to MDT in wound healing.en_US
dc.identifier.citationTombulturk, F. K., & Kanigur-Sultuybek, G. (2021). A molecular approach to maggot debridement therapy with Lucilia sericata and its excretions/secretions in wound healing. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 10.1111/wrr.12961. Advance online publication. https://doi.org/10.1111/wrr.12961en_US
dc.identifier.doi10.1111/wrr.12961en_US
dc.identifier.pmid34343386en_US
dc.identifier.scopus2-s2.0-85111796316en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1111/wrr.12961
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1981
dc.identifier.wosWOS:000680590700001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTombultürk, Fatma Kübra
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofWound Repair and Regenerationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLucilia Sericataen_US
dc.subjectChronic Wound Healingen_US
dc.subjectExcretions/secretionsen_US
dc.subjectMaggot Debridement Therapyen_US
dc.subjectMolecular Effectsen_US
dc.titleA molecular approach to maggot debridement therapy with Lucilia sericata and its excretions/secretions in wound healingen_US
dc.typeArticleen_US

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