Evaluation of predisposing metabolic risk factors for portopulmonary hypertension in patients with NASH cirrhosis

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dc.authorscopusidErdem Koçak / 15728184000
dc.authorwosidErdem Koçak / JGU-4032-2023
dc.contributor.authorTürker, Fatih
dc.contributor.authorŞahin, Tolga
dc.contributor.authorOral, Alihan
dc.contributor.authorKoçak, Erdem
dc.contributor.authorÇavuşoğlu Türker, Betül
dc.contributor.authorNiğdelioğlu, Adil
dc.contributor.authorAtaoğlu, Hayriye Esra
dc.date.accessioned2022-02-07T08:28:47Z
dc.date.available2022-02-07T08:28:47Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: Metabolic parameters are important for the development of portopulmonary hypertension (PoPH) during nonalcoholic steatohepatitis (NASH)-associated cirrhosis. This study evaluated patients with NASH-associated cirrhosis to determine metabolic risk factors for portopulmonary hypertension. Patients and methods: Data on 171 patients (120 men and 51 women) with NASH-associated cirrhosis who were seen in Florence Nightingale Hospital's gastroenterology Clinic from 2009 to 2018 was obtained from the Hospital database. A pulmonary artery systolic pressure >35 mmHg was defined as PH (pulmonary hypertension) according to standard transthoracic echocardiography. Portal hypertension was diagnosed from clinical symptoms and dilated portal veins shown by abdominal ultrasound or computed tomography (CT). Pulmonary patients with portal hypertension were diagnosed with portopulmonary hypertension (PoPH). Results: A total of 171 patients with NASH-associated cirrhosis were included in this study. Of these, 43 patients had PoPH. These patients had increased TSH (p=0.004), bilirubin (p=0.023) and triglyceride (p=0.048) levels, higher MELD scores (p=0.018) and decreased hemoglobin (p=0.05). MELD score and hemoglobin, total bilirubin, TSH, and triglyceride levels were all included in a multivariate logistic regression model and TSH levels were independently associated with increased risk of PoPH. Conclusion: Increased TSH is an independent risk factor for PoPH.en_US
dc.identifier.citationTürker F, Sahın T, Oral A, Koçak E, Çavuşoğlu Türker B, Niğdelioğlu A, Esra Ataoğlu H. Evaluation of Predisposing Metabolic Risk Factors for Portopulmonary Hypertension in Patients with NASH Cirrhosis. Int J Gen Meden_US
dc.identifier.doi10.2147/IJGM.S339474en_US
dc.identifier.endpage865en_US
dc.identifier.pmid35115812en_US
dc.identifier.scopus2-s2.0-85124335914en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage859en_US
dc.identifier.urihttps://doi.org/10.2147/IJGM.S339474
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2465
dc.identifier.volume15en_US
dc.identifier.wosWOS:000753768200002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKoçak, Erdem
dc.language.isoenen_US
dc.relation.ispartofInt J Gen Meden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNASH Cirrhosisen_US
dc.subjectPortopulmonary Hypertensionen_US
dc.subjectPulmonary Hypertensionen_US
dc.titleEvaluation of predisposing metabolic risk factors for portopulmonary hypertension in patients with NASH cirrhosisen_US
dc.typeArticleen_US

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