The effect of fundectomy on histopathological findings and metabolic hormones in rats

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dc.authoridVartanoglu Aktokmakyan, Talar/0000-0003-0583-6440
dc.authoridCAY, TUGCE/0000-0002-4385-2137
dc.authorwosidVartanoglu Aktokmakyan, Talar/AFI-3036-2022
dc.authorwosidMeriç, Serhat/AAI-9670-2021
dc.contributor.authorBugdayci, Nihat
dc.contributor.authorAktokmakyan, Talar Vartanoglu
dc.contributor.authorTokocin, Merve
dc.contributor.authorMeric, Serhat
dc.contributor.authorErcan, Gulcin
dc.contributor.authorKirankaya, Aysegul
dc.contributor.authorCay, Tugce
dc.date.accessioned2024-05-19T14:39:16Z
dc.date.available2024-05-19T14:39:16Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractThe effect of fundectomy on histopathological findings and metabolic hormones in rats AIM: Fundectomy, shown as an alternative to restrictive techniques, causes absorption restriction and metabolic changes. This study aimed to examine the histopathological changes caused by the fundectomy as a technique applied to rats by hormones that affect stomach and obesity metabolism and its effect on weight loss. MATERIAL AND METHODS: 2randomly selected Winstar-Hannover rat groups were evaluated by measuring their pre-and postoperative weights and biochemically measuring Gastrin, Ghrelin, and Leptin levels on day 30. After sacrifi cation, the stomachs were taken for histopathological examination. RESULTS: Significant weight loss was observed in the fundectomy group in the 1stmonth postoperatively. Biochemically, Gastrin means in the fundectomy group were statistically significantly higher than in the control group. The mean Ghrelin and Leptin levels of the Fundectomy Group were statistically significantly lower (p=0.005). Immunohistochemically, Gastrin means TMat the antrum and proximal stomach parts of the Fundectomy Group were significantly higher than in the control group. As Ghrelin, a significant decrease was observed in all 3regions of the Fundectomy Group compared to the control group. Leptin results were significantly lower at the antrum and proximal stomach parts of the Fundectomy Group. Histopathologically, in the Fundectomy Group, cystic glandular hyperplasia was moderate at the proximal stomach, foveolar hyperplasia was mild at the antrum, fibrosis was moderate at the antrum and corpus, and high at the proximal stomach. CONCLUSION: Fundectomy is an effective method in terms of weight loss. This animal experiment, conducted as a pilot study, will be an essential step in elucidating metabolic and histopathological changes.en_US
dc.identifier.endpage315en_US
dc.identifier.issn0003-469X
dc.identifier.issn2239-253X
dc.identifier.issue3en_US
dc.identifier.pmid37530041en_US
dc.identifier.scopus2-s2.0-85166076643en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage309en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4741
dc.identifier.volume94en_US
dc.identifier.wosWOS:001057815800015en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherEdizioni Luigi Pozzien_US
dc.relation.ispartofAnnali Italiani Di Chirurgiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectBariatric Surgeryen_US
dc.subjectFundectomyen_US
dc.subjectObesityen_US
dc.titleThe effect of fundectomy on histopathological findings and metabolic hormones in ratsen_US
dc.typeArticleen_US

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