Evaluating deposited radiation energy amount and collision quantities of small-molecule radiosensitizers through Monte Carlo simulations

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dc.authorscopusidHüseyin Ozan Tekin / 56971130700
dc.authorwosidHüseyin Ozan Tekin / J-9611-2016
dc.contributor.authorAlmisned, Ghada
dc.contributor.authorKılıç, Ceyda Sibel
dc.contributor.authorAlmansoori, Asma
dc.contributor.authorMesbahi, A.
dc.contributor.authorHamad, Mawieh
dc.contributor.authorTekin, Hüseyin Ozan
dc.date.accessioned2025-04-18T09:47:06Z
dc.date.available2025-04-18T09:47:06Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Bilgisayar Mühendisliği Bölümü
dc.description.abstractThis study investigates the photon interaction mechanism of various small molecule radiosensitizers, including Hydrogen Peroxide, Nimorazole, 5-Fluorouracil, NVX-108, and others, using the MCNP 6.3 Monte Carlo simulation code. The simulations focused on quantifying the linear attenuation coefficients, mean free path, and accumulation factors of these radiosensitizers, as well as their interactions in a simulated spherical water phantom irradiated with a 100 keV mono-energetic X-ray source. Our findings reveal significant variations in deposited energy, collision events, and mean free path among the radiosensitizers, indicating different efficacy levels in enhancing radiation therapy. Notably, NVX-108 demonstrated the highest energy deposition, suggesting its potential as a highly effective radiosensitizer. The study also examined the individual attenuation properties of these radiosensitizers against energetic photons, with NVX-108 showing the highest attenuation coefficient and a shorter mean free path, further supporting its superior potential in effective radiosensitization. It can be concluded that NVX-108 has higher interaction tendency with the energetic photons comparing other small-molecules under investigation.
dc.description.sponsorshipPrincess Nourah bint Abdulrahman University
dc.identifier.citationALMisned, G., Kilic, C. S., Almansoori, A., Mesbahi, A., Hamad, M., & Tekin, H. O. (2024). Evaluating deposited radiation energy amount and collision quantities of small-molecule radiosensitizers through Monte Carlo simulations. Heliyon, 10(13).
dc.identifier.doi10.1016/j.heliyon.2024.e33734
dc.identifier.endpage10
dc.identifier.issn2405-8440
dc.identifier.issue13
dc.identifier.pmid39050474
dc.identifier.scopus2-s2.0-85197564162
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttp://dx.doi.org/10.1016/j.heliyon.2024.e33734
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6860
dc.identifier.volume10
dc.identifier.wosWOS:001286286600001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTekin, Hüseyin Ozan
dc.institutionauthoridHüseyin Ozan Tekin / 0000-0002-0997-3488
dc.language.isoen
dc.publisherCell press
dc.relation.ispartofHeliyon
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRadiosensitizers
dc.subjectRadiation Therapy
dc.subjectMonte Carlo Simulation
dc.subjectNVX-108
dc.subjectCancer Treatment
dc.titleEvaluating deposited radiation energy amount and collision quantities of small-molecule radiosensitizers through Monte Carlo simulations
dc.typeArticle

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