Improving effects of mesenchymal stem cells on symptoms of chronic obstructive pulmonary disease

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dc.authoridErdal Karaöz / 0000-0002-9992-833Xen_US
dc.authoridFerah Ece / 0000-0001-6917-0823
dc.authorscopusidErdal Karaöz / 7003448087
dc.authorscopusidFerah Ece / 55883980400
dc.authorwosidErdal Karaöz / IXE-6677-2023
dc.authorwosidFerah Ece / F-8000-2015
dc.authorwosidSerdar Kalemci / HGM-6402-2022
dc.contributor.authorKaraöz, Erdal
dc.contributor.authorKalemci, Serdar
dc.contributor.authorEce, Ferah
dc.date.accessioned2020-08-30T20:06:20Z
dc.date.available2020-08-30T20:06:20Z
dc.date.issued2020
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractAIM: We aimed to identify the improving effects of umbilical cord tissue-derived (UCTD) MSCs on the symptoms of COPD in our phase 1.2 clinical study. MATERIAL METHODS: Our study consisted of five patients with COPD. Respiratory function tests, SGRQ symptom, activity and impact scores and 6-minute walk test (6MWT) were examined before UCTD MSC treatment. All the patients were administered a total of 4 doses of UCTD MSCs by intravenous infusion at two-week intervals. All the tests were repeated three months after the treatment for evaluation of the response to MSCs treatment. RESULTS: The mean age of five male patients was 56. The mean pretreatment FEV1/FVC ratios were 66.9 %. Pretreatment mean SGRQ symptom, activity and impact scores of the patients were 78.2, 83.8 and 58.02 respectively. The mean walking distance of the patients was 307 meters before MSCs treatment. The mean FEV1/FVC value of raised to 69.58 % after the treatment. The mean SGRQ symptom, activity and impact scores were noted as 39.8, 60.98 and 45.18 respectively. The mean walking distance of the patients raised to 362 meters after the treatment. CONCLUSIONS: Our results showed that four doses of MSC treatment considerably alleviated the severity of symptoms of COPD (Tab. 2, Fig. 7, Ref. 25).en_US
dc.identifier.citationKaraoz, E., Kalemci, S., & Ece, F. (2020). Improving effects of mesenchymal stem cells on symptoms of chronic obstructive pulmonary disease.en_US
dc.identifier.doi10.4149/BLL_2020_028en_US
dc.identifier.endpage191en_US
dc.identifier.issn0006-9248en_US
dc.identifier.issn1336-0345en_US
dc.identifier.issue3en_US
dc.identifier.pmid32115975en_US
dc.identifier.scopus2-s2.0-85080840655en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage188en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2020_028
dc.identifier.urihttps://hdl.handle.net/20.500.12713/476
dc.identifier.volume121en_US
dc.identifier.wosWOS:000528258200003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKaraöz, Erdalen_US
dc.institutionauthorKalemci, Serdaren_US
dc.institutionauthorEce, Ferahen_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDisease Progressionen_US
dc.subjectMesenchymal Stromal Cellsen_US
dc.subjectChronic Obstructive Pulmonary Diseaseen_US
dc.subjectUmbilical Cord Tissueen_US
dc.titleImproving effects of mesenchymal stem cells on symptoms of chronic obstructive pulmonary diseaseen_US
dc.typeArticleen_US

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