Pre and postnatal exposure to 900 MHz electromagnetic fields induce inflammation and oxidative stress, and alter renin-angiotensin system components differently in male and female offsprings

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dc.contributor.authorKilic, Aysu
dc.contributor.authorUstunova, Savas
dc.contributor.authorBulut, Huri
dc.contributor.authorMeral, Ismail
dc.date.accessioned2024-05-19T14:41:10Z
dc.date.available2024-05-19T14:41:10Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractAims: This study was designed to investigate inflammation, oxidative stress and renin-angiotensin system components in brain and kidney tissues of female and male rats prenatally and/or postnatally exposed to 900 MHz electromagnetic field (EMF). It is aimed to evaluate the biological effects of 900 MHz EMF exposure due to the increase in mobile phone use and especially the more widespread use of the GSM 900 system. Main methods: Male and female Wistar albino offsprings were divided into four groups of control, prenatal, postnatal, and prenatal+postnatal exposed to 900 MHz EMF for 1 h/day (23 days during pregnancy for prenatal period, 40 days for postnatal period). The brain and kidney tissues were collected when they reached puberty. Key findings: It was found that the total oxidant status, IL-2, IL-6, and TNF-& alpha; levels increased (p < 0.001) and the total antioxidant status levels decreased (p < 0.001) in all three EMF groups comparing to controls in both male and female brain and kidney tissues. The renin- angiotensin system components such as angiotensinogen, renin, angiotensin type 1 and type 2 receptors, and MAS1-like G protein-coupled receptor expression were higher (p < 0.001) in all three EMF exposure groups comparing to controls in both male and female brain and kidney tissues. Although there are some differences of the levels of proinflammatory markers, ROS components and RAS components in brain and kidney tissues between males and females, the common result of all groups was increase in oxidative stress, inflammation markers and angiotensin system components with exposure to 900 MHz EMF. Significance: In conclusion, our study suggested that the 900 MHz EMF can activate brain and kidney reninangiotensin system, and this activation is maybe related to inflammation and oxidative stress in both male and female offsprings.en_US
dc.identifier.doi10.1016/j.lfs.2023.121627
dc.identifier.issn0024-3205
dc.identifier.issn1879-0631
dc.identifier.pmid36997060en_US
dc.identifier.scopus2-s2.0-85151245334en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org10.1016/j.lfs.2023.121627
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5072
dc.identifier.volume321en_US
dc.identifier.wosWOS:001025829500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofLife Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectElectromagnetic Fieldsen_US
dc.subjectBrainen_US
dc.subjectInflammationen_US
dc.subjectKidneyen_US
dc.subjectOffspringen_US
dc.subjectOxidative Stressen_US
dc.subjectRenin-Angiotensin Systemen_US
dc.titlePre and postnatal exposure to 900 MHz electromagnetic fields induce inflammation and oxidative stress, and alter renin-angiotensin system components differently in male and female offspringsen_US
dc.typeArticleen_US

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