Crosstalk of Transcriptional Regulators of Adaptive Immune System and microRNAs: An Insight into Differentiation and Development

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dc.authoridMirian, Mina/0000-0002-9322-2707
dc.authoridRahimmanesh, Ilnaz/0000-0003-3438-1959
dc.authoridZarrabi, Ali/0000-0003-0391-1769
dc.authoridZarepour, Atefeh/0000-0002-0347-5840
dc.authorwosidMirian, Mina/AHA-6980-2022
dc.authorwosidRahimmanesh, Ilnaz/CAA-2321-2022
dc.authorwosidZarrabi, Ali/U-2602-2019
dc.authorwosidZarepour, Atefeh/AAH-9225-2020
dc.contributor.authorBoshtam, Maryam
dc.contributor.authorRahimmanesh, Ilnaz
dc.contributor.authorShariati, Laleh
dc.contributor.authorNajaflu, Malihe
dc.contributor.authorKhanahmad, Hossein
dc.contributor.authorMirian, Mina
dc.contributor.authorZarepour, Atefeh
dc.date.accessioned2024-05-19T14:45:50Z
dc.date.available2024-05-19T14:45:50Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractMicroRNAs (miRNAs), as small regulatory RNA molecules, are involved in gene expression at the post-transcriptional level. Hence, miRNAs contribute to gene regulation of various steps of different cell subsets' differentiation, maturation, and activation. The adaptive immune system arm, which exhibits the most specific immune responses, is also modulated by miRNAs. The generation and maturation of various T-cell subsets concomitant with B-cells is under precise regulation of miRNAs which function directly on the hallmark genes of each cell subset or indirectly through regulation of signaling pathway mediators and/or transcription factors involved in this maturation journey. In this review, we first discussed the origination process of common lymphocyte progenitors from hematopoietic stem cells, which further differentiate into various T-cell subsets under strict regulation of miRNAs and transcription factors. Subsequently, the differentiation of B-cells from common lymphocyte progenitors in bone marrow and periphery were discussed in association with a network of miRNAs and transcription factors.en_US
dc.identifier.doi10.3390/cells12040635
dc.identifier.issn2073-4409
dc.identifier.issue4en_US
dc.identifier.pmid36831302en_US
dc.identifier.scopus2-s2.0-85148897894en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org10.3390/cells12040635
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5361
dc.identifier.volume12en_US
dc.identifier.wosWOS:000938698400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofCellsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectMirnaen_US
dc.subjectSignaling Pathway Mediatorsen_US
dc.subjectAdaptive Immune Systemen_US
dc.subjectT-Cellsen_US
dc.subjectB-Cellsen_US
dc.titleCrosstalk of Transcriptional Regulators of Adaptive Immune System and microRNAs: An Insight into Differentiation and Developmenten_US
dc.typeReview Articleen_US

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