Antibacterial effects of quercetagetin are significantly enhanced upon conjugation with chitosan engineered copper oxide nanoparticles

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dc.authoridKhan, Naveed/0000-0001-7667-8553
dc.authoridSiddiqui, Ruqaiyyah/0000-0001-9646-6208
dc.authoridAkbar, Noor/0000-0002-8114-1969
dc.authorwosidKhan, Naveed/AAM-2892-2021
dc.authorwosidShah, Muhammad Raza/AAR-3981-2021
dc.authorwosidSiddiqui, Ruqaiyyah/AIF-2100-2022
dc.authorwosidKhan, Naveed/KCK-0156-2024
dc.contributor.authorAlvi, Adeelah
dc.contributor.authorAlqassim, Saif
dc.contributor.authorKhan, Naveed Ahmed
dc.contributor.authorKhatoon, Bushra
dc.contributor.authorAkbar, Noor
dc.contributor.authorKawish, Muhammad
dc.contributor.authorFaizi, Shaheen
dc.date.accessioned2024-05-19T14:40:27Z
dc.date.available2024-05-19T14:40:27Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractThe development of antibiotic alternatives that entail distinctive chemistry and modes of action is necessary due to the threat posed by drug resistance. Nanotechnology has gained increasing attention in recent years, as a vehicle to enhance the efficacy of existing antimicrobials. In this study, Chitosan copper oxide nanoparticles (CHI-CuO) were synthesized and were further loaded with Quercetagetin (QTG) to achieve the desired (CHI-CuO-QTG). Size distribution, zeta potential and morphological analysis were accomplished. Next, the developed CHI-CuO-QTG was assessed for synergistic antibacterial properties, as well as cytotoxic attributes. Bactericidal assays revealed that CHI-CuO conjugation showed remarkable effects and enhanced QTG effects against a range of Gram + ve and Gram - ve bacteria. The MIC50 of QTG against S. pyogenes was 107 mu g/mL while CHI-CuO-QTG reduced it to 9 mu g/mL. Similar results were observed when tested against S. pneumoniae. Likewise, the MIC50 of QTG against S. enterica was 38 mu g/mL while CHI-CuO-QTG reduced it to 7 mu g/mL. For E. coli K1, the MIC50 of QTG was 42 mu g/mL while with CHI-CuO-QTG it was 23 mu g/mL. Finally, the MIC50 of QTG against S. marcescens was 98 mu g/mL while CHI-CuO-QTG reduced it to 10 mu g/mL. Notably, the CHI-CuO-QTG nano-formulation showed limited damage when tested against human cells using lactate dehydrogenase release assays. Importantly, bacterial-mediated human cell damage was reduced by prior treatment of bacteria using drug nano-formulations. These findings are remarkable and clearly demonstrate that drug-nanoparticle formulations using nanotechnology is an important avenue in developing potential therapeutic interventions against microbial infections.en_US
dc.description.sponsorshipAir Force Office of Scientific Research (AFOSR), USAen_US
dc.description.sponsorshipRuqaiyyah Siddiqui and Naveed Ahmed Khan are supported by the Air Force Office of Scientific Research (AFOSR), USAen_US
dc.identifier.doi10.1007/s10534-023-00539-0
dc.identifier.endpage184en_US
dc.identifier.issn0966-0844
dc.identifier.issn1572-8773
dc.identifier.issue1en_US
dc.identifier.pmid37792257en_US
dc.identifier.scopus2-s2.0-85173952667en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage171en_US
dc.identifier.urihttps://doi.org10.1007/s10534-023-00539-0
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4962
dc.identifier.volume37en_US
dc.identifier.wosWOS:001078491700002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofBiometalsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectCopper Oxideen_US
dc.subjectQuercetagetinen_US
dc.subjectNanoparticlesen_US
dc.subjectChitosan Copper Oxide Nanoparticlesen_US
dc.titleAntibacterial effects of quercetagetin are significantly enhanced upon conjugation with chitosan engineered copper oxide nanoparticlesen_US
dc.typeArticleen_US

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