Predictors of intraventicular hemorhage in the neonatal intensive care unit

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dc.authoridHakan Ongun / 0000-0002-4671-4872
dc.authorscopusidHakan Ongun / 8851884100
dc.authorwosidHakan Ongun / AAP-8851-2021
dc.contributor.authorOngun, Hakan
dc.contributor.authorÖzyazıcı Özkan, Sarıye Elif
dc.date.accessioned2021-04-26T09:52:59Z
dc.date.available2021-04-26T09:52:59Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Hastaneen_US
dc.description.abstractAim: To analyze intraventricular hemorrhage (IVH) incidence, clinical features and risk factors in extremely low birth weight infants. Materials and Method(s): It is a single-center, retrospective cohort in infants delivering neonatal intensive care between 2010 and 2019. Infants of birth weight <1000 grams who had transfontanel-ultrasounds in the first week of life were included. Postnatal transfers, central nervous system anomalies, antenatal-diagnosed hemorrhage, death before obtaining transfontanel-ultrasound and incomplete dataset were excluded from the study. Infants were categorized as mild IVHs (grades 1-2), severe IVHs (grade-3, periventricular-hemorrhagic infarct) and control group. Ante-perinatal characteristics, clinical and laboratory features were recorded. SPSS23 program utilized analysis for three groups. Results: Overall IVH incidence was 22.9% in 455 neonates (52.9%, 49%, 31.5%, 13.4%, 6.7% at =25, 26, 27, 28 and 29 gestational weeks. Seizure was the first sign in 32.7% of the infants. Neonatal resuscitation, umbilical-cord blood pH, chorioamnionitis, patent ductus arteriosus were associated with developing mild IVH, but did not influence the progression to severe hemorrhage (p=0.782, p=0.109, p=0.566, p=0.111). Gestational age, invasive mechanical ventilation, inotrope-required hypotension was related to high-grade IVHs (p<0.001, p=0.025, p=0.013). The predictive strength of platelets to define IVH was poor at intensive care admission (sensitivity: 74%, specificity: 68.3%). Inotrope-required hypotension and low-umbilical-cord blood pH were determined as independent risk factors of high-grade IVHs (OR: 6.678, 95% CI: 2.557-17.443 and OR: 3.554, 95%CI: 1.089-11.602). Four infants necessitated ventriculo-peritoneal shunting. Mortality was 23.1% in infants developing IVH. Conclusion: Inotrope-required hypotension is the strongest predisposing factor for high-grade ventricular hemorrhage in extremely low birth weight infants.en_US
dc.identifier.citationONGUN, H., OZYAZICI OZKAN, S. E., (2021) Predictors of Intraventicular Hemorhage in the Neonatal Intensive Care Unit. Journal of Critical Care & Intensive Care, 12(1), p1-7, 7pen_US
dc.identifier.doi10.37678/dcybd.2021.2583en_US
dc.identifier.endpage7en_US
dc.identifier.issn2717-6428en_US
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85104882116en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1en_US
dc.identifier.trdizinid490362en_US
dc.identifier.urihttps://www.doi.org/10.37678/dcybd.2021.2583
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1709
dc.identifier.volume12en_US
dc.identifier.wosWOS:000637214000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorOngun, Hakan
dc.language.isoenen_US
dc.publisherTURKISH SOC MEDICAL & SURGICAL INTENSIVE CARE MEDICINEen_US
dc.relation.ispartofJOURNAL OF CRITICAL & INTENSIVE CAREen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntraventricular Hemorrhageen_US
dc.subjectPrematurityen_US
dc.subjectExtremely Low Birth Weighten_US
dc.subjectRisk Factorsen_US
dc.titlePredictors of intraventicular hemorhage in the neonatal intensive care uniten_US
dc.typeArticleen_US

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