Photocurable silk fibroin-based tissue sealants with enhanced adhesive properties for the treatment of corneal perforations

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dc.authoridAyça Bal Öztürk / 0000-0002-6502-528Xen_US
dc.authoridBurçin İzbudak / 0000-0002-5572-7966
dc.authorscopusidAyça Bal Öztürk / 57062000100
dc.authorscopusidBurçin İzbudak / 57221779519
dc.authorwosidBurçin İzbudak / GXP-7807-2022
dc.authorwosidAyça Bal Öztürk / M-4472-2018
dc.contributor.authorTutar, Rümeysa
dc.contributor.authorYüce Erarslan, Elif
dc.contributor.authorİzbudak, Burçin
dc.contributor.authorBal Öztürk, Ayça
dc.date.accessioned2022-03-23T05:51:31Z
dc.date.available2022-03-23T05:51:31Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Temel Bilimleri Bölümüen_US
dc.description.abstractCorneal defects are associated with corneal tissue engineering in terms of vision loss. The treatment of corneal defects is an important clinical challenge due to a uniform corneal thickness and the apparent lack of regenerative ability. In this work, we synthesized a biocompatible and photocrosslinkable ocular tissue adhesive composite hydrogel prepared by using methacrylated gelatin (GelMA), which is called the most favorable derivative of gelatin used as a tissue adhesive, silk fibroin (SF), and GelMA/SF (GS) with high adhesion behaviours for use in corneal injuries. The adhesion behaviours of the materials prepared in the presence of silk fibroin were improved. Importantly, the effect of different UV curing times on the adhesion properties of the prepared materials was also investigated. The prepared GS tissue adhesives showed high physiological adhesion. GS can be modulated to increase its adhesive strength up to 3 times compared to G. GS was also found to be biocompatible and have a high healing potential. In addition, the obtained transmission value of GS is also close to that of the human cornea. GS supported cellular adhesion and proliferation. The burst pressure strength for fresh cornea of the GS-60s sealants (144.5 ± 13 kPa) was determined to be higher than that of the G-60s sealants (52.6 ± 33.5 kPa).en_US
dc.identifier.citationTutar R, Yüce-Erarslan E, İzbudak B, Bal-Öztürk A. Photocurable silk fibroin-based tissue sealants with enhanced adhesive properties for the treatment of corneal perforations. J Mater Chem B. 2022 Mar 17.en_US
dc.identifier.doi10.1039/d1tb02502cen_US
dc.identifier.pmid35297911en_US
dc.identifier.scopus2-s2.0-85127561383en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1039/d1tb02502c
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2565
dc.identifier.wosWOS:000770074300001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorİzbudak, Burçin
dc.institutionauthorBal Öztürk, Ayça
dc.language.isoenen_US
dc.relation.ispartofJ Mater Chem B .en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titlePhotocurable silk fibroin-based tissue sealants with enhanced adhesive properties for the treatment of corneal perforationsen_US
dc.typeArticleen_US

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