Differentiation of claustrum resting-state functional connectivity in healthy aging, alzheimer's disease, and parkinson's disease

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dc.authoridSevilay Ayyıldız / 0000-0001-6870-8177en_US
dc.authoridBehçet Ayyıldız / 0000-0003-1750-4099en_US
dc.authorscopusidSevilay Ayyıldız / 57807205200en_US
dc.authorscopusidBehçet Ayyıldız / 57269886300en_US
dc.authorwosidSevilay Ayyıldız / GNY-0869-2022en_US
dc.authorwosidBehçet Ayyıldız / AAR-5486-2020en_US
dc.contributor.authorAyyıldız, Sevılay
dc.contributor.authorVelioğlu, Halil Aziz
dc.contributor.authorAyyıldız, Behçet
dc.contributor.authorSütçübaşı, Bernis
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorBayraktaroğlu, Zübeyir
dc.contributor.authorYıldırım, Süleyman
dc.contributor.authorAtasever, Alper
dc.contributor.authorYuluğ, Burak
dc.date.accessioned2022-12-30T07:55:27Z
dc.date.available2022-12-30T07:55:27Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractThe claustrum is a sheet-like of telencephalic gray matter structure whose function is poorly understood. The claustrum is considered a multimodal computing network due to its reciprocal connections with almost all cortical areas as well as subcortical structures. Although the claustrum has been involved in several neurodegenerative diseases, specific changes in connections of the claustrum remain unclear in Alzheimer's disease (AD), and Parkinson's disease (PD). Resting-state fMRI and T1-weighted structural 3D images from healthy elderly (n = 15), AD (n = 16), and PD (n = 12) subjects were analyzed. Seed-based FC analysis was performed using CONN FC toolbox and T1-weighted images were analyzed with the Computational Anatomy Toolbox for voxel-based morphometry analysis. While we observed a decreased FC between the left claustrum and sensorimotor cortex, auditory association cortex, and cortical regions associated with social cognition in PD compared with the healthy control group (HC), no significant difference was found in alterations in the FC of both claustrum comparing the HC and AD groups. In the AD group, high FC of claustrum with regions of sensorimotor cortex and cortical regions related to cognitive control, including cingulate gyrus, supramarginal gyrus, and insular cortex were demonstrated. In addition, the structural results show significantly decreased volume in bilateral claustrum in AD and PD compared with HC. There were no significant differences in the claustrum volumes between PD and AD groups so the FC may offer more precise findings in distinguishing changes for claustrum in AD and PD.en_US
dc.identifier.citationAyyildiz, S., Velioglu, H. A., Ayyildiz, B., Sutcubasi, B., Hanoglu, L., Bayraktaroglu, Z., Yildirim, S., Atasever, A., & Yulug, B. (2022). Differentiation of claustrum resting-state functional connectivity in healthy aging, Alzheimer's disease, and Parkinson's disease. Human brain mapping, 10.1002/hbm.26171. Advance online publication. https://doi.org/10.1002/hbm.26171en_US
dc.identifier.issn1065-9471en_US
dc.identifier.pmid36515182en_US
dc.identifier.scopus2-s2.0-85144158480en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttp://dx.doi.org/10.1002/hbm.26171
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3784
dc.identifier.wosWOS:000896959900001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAyyıldız, Sevilay
dc.institutionauthorAyyıldız, Behçet
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofHuman Brain Mappingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlzheimer's Diseaseen_US
dc.subjectParkinson's Diseaseen_US
dc.subjectClaustrumen_US
dc.subjectElderly Peopleen_US
dc.subjectFunctional Connectivityen_US
dc.titleDifferentiation of claustrum resting-state functional connectivity in healthy aging, alzheimer's disease, and parkinson's diseaseen_US
dc.typeArticleen_US

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