Novel magnetic embolic MRI imageable particles with anticancer drug release for transcatheter arterial embolization and magnetic ablation

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dc.authoridFuad Nurili / 0000-0002-0413-9363
dc.authorscopusidFuad Nurilli / 56178012700en_US
dc.contributor.authorBekaroğlu, Maide Gökçe
dc.contributor.authorNurili, Fuad
dc.contributor.authorCaymaz, İsmail
dc.contributor.authorBaş, Ahmet
dc.contributor.authorİşçi, Sevim
dc.date.accessioned2022-12-21T08:04:03Z
dc.date.available2022-12-21T08:04:03Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Hastaneen_US
dc.description.abstractThe aim of the study is to prepare embolic hydroxyl ethyl cellulose (HEC)-polyvinyl prolidone (PVP)-magnetic particles suitable for transcatheter arterial chemoembolization (TACE) procedures, drug delivery, and magnetic hyperthermia. Two different sizes (microsized and nanosized) of iron oxide particles were used to prepare the embolic particles to investigate the embolization and drug delivery properties. Iron oxides were linked with PVP via bridging flocculation process, then outermost layer of the linked particles was coated with HEC in order to load drugs to particles and reach size requirements for a successful TACE procedure. Size of each particle was calibrated to the range that allows easy injections through microcatheters (40-500 mu m). The results showed that the size of the final embolic particles reached around 70 mu m with 82 W/g specific absorption rate (SAR) values for nano-iron oxide particles and 45 mu m with 77 W/g SAR values for micro-iron oxide particles, which are quite suitable for TACE applications. Furthermore, an anticancer drug doxorubicin (DOX) was successfully loaded onto these particles in order to achieve localized chemotherapy at the tumor site. Particles produced in this study, loaded DOX successfully and prolonged drug release time, performed similarly to pure DOX at higher concentration treatments against human breast cancer cell lines, were heatable under applied alternating magnetic fields. In addition, in vivo embolization studies performed using a rabbit renal embolization model, indicated that these particles were easily delivered through microcatheters and were able to embolize the target.en_US
dc.identifier.citationBekaroğlu, M. G., Nurili, F., Caymaz, İ., & İşçi, S. (2022). Novel magnetic embolic MRI imageable particles with anticancer drug release for transcatheter arterial embolization and magnetic ablation. Medical Physics.en_US
dc.identifier.doi10.1002/mp.16052en_US
dc.identifier.issn0094-2405en_US
dc.identifier.issn2473-4209en_US
dc.identifier.scopus2-s2.0-85142606327en_US
dc.identifier.urihttp://dx.doi.org/10.1002/mp.16052
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3745
dc.identifier.wosWOS:000890276400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorNurili, Fuad
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofMEDICAL PHYSICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArterial Embolizationen_US
dc.subjectCancer Therapyen_US
dc.subjectDrug Deliveryen_US
dc.subjectImaging Agenten_US
dc.subjectMagnetic Embolic Particlesen_US
dc.titleNovel magnetic embolic MRI imageable particles with anticancer drug release for transcatheter arterial embolization and magnetic ablationen_US
dc.typeArticleen_US

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