Zinc finger protein 384 ( ZNF384) impact on childhood mixed phenotype acute leukemia and B-cell precursor acute lymphoblastic leukemia

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dc.authoridTülin Tiraje Celkan / 0000-0001-7287-1276en_US
dc.authoridGül Nihal Özdemir / 0000-0002-3204-4353en_US
dc.authorscopusidTülin Tiraje Celkan / 35584411200
dc.authorscopusidGül Nihal Özdemir / 57208780173
dc.authorwosidTülin Tiraje Celkan / FZB-3980-2022en_US
dc.authorwosidGül Nihal Özdemir / AAO-9962-2020en_US
dc.contributor.authorSudutan, Tuğce
dc.contributor.authorErbilgin, Yücel
dc.contributor.authorHatırnaz, Özden
dc.contributor.authorKaraman, Serap
dc.contributor.authorKarakaş, Zeynep
dc.contributor.authorKüçükcankurt, Fulya
dc.contributor.authorCelkan, Tülin Tiraje
dc.contributor.authorTimur, Çetin
dc.contributor.authorÖzdemir, Gül Nihal
dc.contributor.authorHacısalihoglu, Sadan
dc.contributor.authorAylan Gelen, Sema
dc.contributor.authorSayitoğlu, Müge
dc.date.accessioned2022-08-08T12:49:38Z
dc.date.available2022-08-08T12:49:38Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractB-cell precursor acute lymphoblastic leukemia (BCP-ALL) is a heterogeneous malignancy and consists of several genetic abnormalities. Some of these abnormalities are used in clinics for risk calculation and treatment decisions. Patients with ZNF384 rearrangements had a distinct expression profile regardless of their diagnosis, BCP-ALL or mixed phenotype acute leukemia (MPAL) and defined as a new subtype of ALL. In this study, we screened 42 MPAL and 91 BCP-ALL patients for the most common ZNF384 fusions; ZNF384::TCF3, ZNF384::EP300 and ZNF384::TAF15 by using PCR. We identified ZNF384 fusions in 9.5% of MPAL and 7.6% of BCP-ALL. A novel breakpoint was identified in ZNF384::TCF3 fusion in one BCP-ALL patient. T-myeloid MPAL patients showed significantly lower ZNF384 expression compared to lymphoid groups. Patients with ZNF384r had intermediate survival rates based on other subtypes. Prognostic and patient-specific treatment evaluation of ZNF384 fusions in both ALL and MPAL might help to improve risk characterization of patients.en_US
dc.identifier.citationSudutan T, Erbilgin Y, Hatirnaz Ng O, Karaman S, Karakas Z, Kucukcankurt F, Celkan T, Timur C, Ozdemir GN, Hacısalihoglu S, Gelen SA, Sayitoğlu M. Zinc finger protein 384 (ZNF384) impact on childhood mixed phenotype acute leukemia and B-cell precursor acute lymphoblastic leukemia. Leuk Lymphoma. 2022 Aug 3:1-9. doi: 10.1080/10428194.2022.2095630. Epub ahead of print. PMID: 35921545.en_US
dc.identifier.doi10.1080/10428194.2022.2095630en_US
dc.identifier.issn1042-8194en_US
dc.identifier.issue9en_US
dc.identifier.pmid35921545en_US
dc.identifier.scopus2-s2.0-85135256086en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttp://doi.org/10.1080/10428194.2022.2095630
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3074
dc.identifier.volume1en_US
dc.identifier.wosWOS:000835775800001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorCelkan, Tülin Tiraje
dc.institutionauthorÖzdemir, Gül Nihal
dc.language.isoenen_US
dc.publisherTaylor and Francisen_US
dc.relation.ispartofLeukemia & Lymphomaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectB-Cell Precursor ALLen_US
dc.subjectZNF384 Expression Levelsen_US
dc.subjectZNF384 Fusionen_US
dc.subjectMixed Phenotype Acute Leukemiaen_US
dc.titleZinc finger protein 384 ( ZNF384) impact on childhood mixed phenotype acute leukemia and B-cell precursor acute lymphoblastic leukemiaen_US
dc.typeArticleen_US

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