A study comparing the effect of premedication with intravenous midazolam or dexmedetomidine on ketamine-fentanyl sedoanalgesia in burn patients: a randomized clinical trial

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dc.authoridMuzaffer Gencer / 0000-0002-3324-5106
dc.authorscopusidMuzaffer Gencer / 57218915766
dc.authorwosidMuzaffer Gencer / EWA-8922-2022
dc.contributor.authorGencer, Muzaffer
dc.contributor.authorSezen, Ozlem K.
dc.date.accessioned2020-12-15T11:43:29Z
dc.date.available2020-12-15T11:43:29Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Görüntüleme Teknikleri Bölümüen_US
dc.description.abstractIntroduction: Dressing changes and wound care-debridement procedures often cause fear and anxiety in burn patients, as these processes are quite painful. In order to determine the best method for alleviating pain during these procedures, the current study compared the efficacy and safety of intravenous dexmedetomidine and midazolam for premedication prior to these painful burn care procedures. Methods: This comparative and randomized study included patients who had a burn size of 1563%, were aged 1870 years, were diagnosed with the American Society of Anesthesiologists physical status (ASA I–II), and who underwent painful burn care procedures. Patients were intravenously administered either 1 mcg/kg dexmedetomidine (Group 1) or 0.03 mg/kg midazolam (Group 2) prior to the burn care procedure. Recorded at predetermined time points for each patient were heart rhythm (HR), mean arterial pressure (MAP), peripheral oxygen saturation (SpO2), standard bispectral index (BIS), and Ramsay Sedation Scale (RSS). Results: In the dexmedetomidine group, HR and MAP measurements of patients ??at the 3rd, 5th, and 10th mins during sedation were significantly lower than the baseline values (p < 0.05). A significant decrease in SpO2 was observed in both groups at the 10th min during sedation, but the decline was higher in the midazolam group (p < 0.05). BIS measurements of the patients in both groups were significantly lower at 10 min. during sedation and at 15th and 60th mins during the procedure (p < 0.05). However, there was no significant difference between the group (p > 0.05). The RSS scales of both groups in during the sedation were higher in the 3rd, 5th and 10th mins than the baseline values (p < 0.05), but there was no significant difference between the groups (p > 0.05). The RSS scales of groups in during the burn procedure were significantly higher at 15 th min than the 0 th values, while the RSS scales of both groups were significantly lower in the 45th and 60th mins (p < 0.05). Conclusion: Results of this study indicate that dexmedetomidine causes hemodynamic alterations while midazolam causes respiratory depression. However, these effects are not severe, and we conclude that both agents are safe and effective to ensure sedation prior to painful burn-care procedures.en_US
dc.identifier.citationGencer, M., & Sezen, O. (2020). A study comparing the effect of premedication with intravenous midazolam or dexmedetomidine on ketamine-fentanyl sedoanalgesia in burn patients: A randomized clinical trial. Burns.en_US
dc.identifier.doi10.1016/j.burns.2020.05.027en_US
dc.identifier.issn0305-4179en_US
dc.identifier.pmid33277091en_US
dc.identifier.scopus2-s2.0-85096965202en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://www.doi.org/10.1016/j.burns.2020.05.027
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1275
dc.identifier.wosWOS:000608468400011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGencer, Muzaffer
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofBurnsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBurn Dressing Changeen_US
dc.subjectDexmedetomidineen_US
dc.subjectMidazolamen_US
dc.subjectPremedicationen_US
dc.titleA study comparing the effect of premedication with intravenous midazolam or dexmedetomidine on ketamine-fentanyl sedoanalgesia in burn patients: a randomized clinical trialen_US
dc.typeArticleen_US

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