A review on hydrogen sulfide: Is it pro-nociceptive or anti-nociceptive?

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dc.authoridHazal Eken / 0000-0003-2360-511X
dc.authorwosidHazal Eken / GLV-1177-2022
dc.contributor.authorEken, Hazal
dc.contributor.authorBektas, Nurcan
dc.contributor.authorArslan, Rana
dc.date.accessioned2022-06-09T13:47:43Z
dc.date.available2022-06-09T13:47:43Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractPain is sensed by the activation of painful nociceptors in the periphery or by pain mediators, such as bradykinin, serotonin, histamine, and prostaglandin, released from the damaged tissue, afferent transmission to the medulla spinalis, and by transmission stages to the high centers over the dorsal horn. Pain, which was seen as only a warning sign in the past, is now accepted as a phenomenon in itself that needs to be treated and the search for new, stronger active substances with fewer side effects in the treatment of pain is in demand. Hydrogen sulfide (H2S) is a modulator of T-type Ca+2 channels, especially in Cav3.2, which are known to play a critical role in the processing of pain. H2S can also show an anti-nociceptive effect by opening K+ channels and blocking nociceptors. Exciting preclinical data has demonstrated that H2S-derived Non-steroidal anti-inflammatory drugs (NSAIDs) and analgesic agents can be used to treat various types of pain. H2S increases the resistance of gastric mucosa against injury occurred by drugs used for pain relief and accelerates its repair, so it provides an advantage to derivatized drugs. In addition, H2S donors have also been shown to induce analgesia through mu-opioid receptors. Based on the studies, it is thought that the combination of H2S with opioid receptor agonists may provide an additive or even synergistic analgesic effect. It is estimated that the modification of H2S, with currently used analgesic drugs to prevent various side effects and increase analgesic effects, is a promising and wise approach.en_US
dc.identifier.citationEken, H., Bektaş Türkmen, N., Arslan, R. (2022). A review on hydrogen sulfide: Is it pro-nociceptive or anti-nociceptive?. İstanbul Journal of Pharmacy 52(1), 101–107.en_US
dc.identifier.doi10.26650/IstanbulJPharm.2022.913936en_US
dc.identifier.endpage107en_US
dc.identifier.issn2587-2087en_US
dc.identifier.issue1en_US
dc.identifier.startpage101en_US
dc.identifier.trdizinid1127043en_US
dc.identifier.urihttps://doi.org/10.26650/IstanbulJPharm.2022.913936
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2858
dc.identifier.volume52en_US
dc.identifier.wosWOS:000793925000015en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorEken, Hazal
dc.language.isoenen_US
dc.publisherISTANBUL UNIVen_US
dc.relation.ispartofISTANBUL JOURNAL OF PHARMACYen_US
dc.relation.publicationcategoryDiÄŸeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHydrogen Sulfideen_US
dc.subjectPainen_US
dc.subjectAnalgesic Effecten_US
dc.titleA review on hydrogen sulfide: Is it pro-nociceptive or anti-nociceptive?en_US
dc.typeReview Articleen_US

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