Injectable, antibacterial, and oxygen-releasing chitosan-based hydrogel for multimodal healing of bacteria-infected wounds

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dc.authoridZarrabi, Ali/0000-0003-0391-1769
dc.authoridshahbazi, Mohammad-Ali/0000-0002-4860-3017
dc.authorwosidmaleki, aziz/D-5003-2011
dc.authorwosidZarrabi, Ali/U-2602-2019
dc.authorwosidshahbazi, Mohammad-Ali/M-5838-2013
dc.contributor.authorBochani, Shayesteh
dc.contributor.authorZarepour, Atefeh
dc.contributor.authorKalantari-Hesari, Ali
dc.contributor.authorHaghi, Fakhri
dc.contributor.authorShahbazi, Mohammad-Ali
dc.contributor.authorZarrabi, Ali
dc.contributor.authorTaheri, Sophia
dc.date.accessioned2024-05-19T14:50:38Z
dc.date.available2024-05-19T14:50:38Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBacterial infection is one of the main challenges of wound healing. It imposes financial and healthcare costs. The emergence of antibiotic-resistant bacteria has increased concerns about this challenge, and made finding alternative solutions a crucial aim. We created a new, antibacterial, multifunctional hydrogel with synergistic chemodynamic and photothermal features for wound-healing applications. We fabricated a chitosan (CT)-based hydrogel containing tannic acid (TA), Fe, and MnO2 nanosheets (CT-TA-Fe-MnO2) via a simple method and characterized it. The antibacterial features (resulting from the production of reactive oxygen species within bacterial cells) and healing ability (via anti-inflammatory and hemostatic features) of the hydrogel were confirmed in vitro. In vivo results revealed the effectiveness of the CT-TA-Fe-MnO2 hydrogel in decreasing the hemostatic time, improving anti-inflammatory effects, and promoting wound healing during 14 days by enhancing the deposition and maturation of collagen fibers without affecting the vital organs. The fabricated CT-TA-Fe-MnO2 hydrogel could be a promising candidate with antibacterial and anti-inflammatory activities suitable for wound-healing applications.en_US
dc.description.sponsorshipIran National Science Foundation [99015911]; Food and Drug Administration, MOH amp; ME, Tehran, Iran [Pr983902]en_US
dc.description.sponsorshipThis work was supported by the Iran National Science Foundation (no. 99015911) and Food and Drug Administration, MOH & ME, Tehran, Iran (grant no. Pr983902).en_US
dc.identifier.doi10.1039/d3tb01278f
dc.identifier.issn2050-750X
dc.identifier.issn2050-7518
dc.identifier.pmid37545169en_US
dc.identifier.scopus2-s2.0-85168596568en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org10.1039/d3tb01278f
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5767
dc.identifier.wosWOS:001043149100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofJournal of Materials Chemistry Ben_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subject[No Keywords]en_US
dc.titleInjectable, antibacterial, and oxygen-releasing chitosan-based hydrogel for multimodal healing of bacteria-infected woundsen_US
dc.typeArticleen_US

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