Exosomes as promising nanostructures in diabetes mellitus: from insulin sensitivity to ameliorating diabetic complications

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorAshrafizadeh, Milad
dc.contributor.authorKumar, Alan Prem
dc.contributor.authorAref, Amir Reza
dc.contributor.authorZarrabi, Ali
dc.contributor.authorMostafavi, Ebrahim
dc.date.accessioned2022-04-06T05:46:24Z
dc.date.available2022-04-06T05:46:24Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractDiabetes mellitus (DM) is among the chronic metabolic disorders that its incidence rate has shown an increase in developed and wealthy countries due to lifestyle and obesity. The treatment of DM has always been of interest, and significant effort has been made in this field. Exosomes belong to extracellular vesicles with nanosized features (30-150 nm) that are involved in cell-to-cell communication and preserving homeostasis. The function of exosomes is different based on their cargo, and they may contain lipids, proteins, and nucleic acids. The present review focuses on the application of exosomes in the treatment of DM; both glucose and lipid levels are significantly affected by exosomes, and these nanostructures enhance lipid metabolism and decrease its deposition. Furthermore, exosomes promote glucose metabolism and affect the level of glycolytic enzymes and glucose transporters in DM. Type I DM results from the destruction of ? cells in the pancreas, and exosomes can be employed to ameliorate apoptosis and endoplasmic reticulum (ER) stress in these cells. The exosomes have dual functions in mediating insulin resistance/sensitivity, and M1 macrophage-derived exosomes inhibit insulin secretion. The exosomes may contain miRNAs, and by transferring among cells, they can regulate various molecular pathways such as AMPK, PI3K/Akt, and ?-catenin to affect DM progression. Noteworthy, exosomes are present in different body fluids such as blood circulation, and they can be employed as biomarkers for the diagnosis of diabetic patients. Future studies should focus on engineering exosomes derived from sources such as mesenchymal stem cells to treat DM as a novel strategy.en_US
dc.identifier.citationAshrafizadeh, M., Kumar, A. P., Aref, A. R., Zarrabi, A., & Mostafavi, E. (2022). Exosomes as Promising Nanostructures in Diabetes Mellitus: From Insulin Sensitivity to Ameliorating Diabetic Complications. International Journal of Nanomedicine, 17, 1229.en_US
dc.identifier.doi10.2147/IJN.S350250en_US
dc.identifier.issn1229-1253en_US
dc.identifier.pmid35340823en_US
dc.identifier.scopus2-s2.0-85128000234en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.2147/IJN.S350250
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2616
dc.identifier.wosWOS:000773574600002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.relation.ispartofInt J Nanomedicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectExosomeen_US
dc.subjectGlucose Uptakeen_US
dc.subjectInsulin Resistanceen_US
dc.subjectLipid Metabolismen_US
dc.titleExosomes as promising nanostructures in diabetes mellitus: from insulin sensitivity to ameliorating diabetic complicationsen_US
dc.typeReview Articleen_US

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