Molecular landscape of c-Myc signaling in prostate cancer: A roadmap to clinical translation

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100en_US
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorFaskhoudi, M.A.
dc.contributor.authorMolaei, P.
dc.contributor.authorSadrkhanloo, M.
dc.contributor.authorOrouei, S.
dc.contributor.authorHashemi, M.
dc.contributor.authorBokaie, S.
dc.contributor.authorRashidi, M.
dc.contributor.authorEntezari, M.
dc.contributor.authorZarrabi, A.
dc.contributor.authorHushmandi, K.
dc.contributor.authorMirzaei, S.
dc.contributor.authorGholami, M.H.
dc.date.accessioned2022-04-06T05:37:50Z
dc.date.available2022-04-06T05:37:50Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractThe c-Myc signaling is a new emerging target in cancer therapy. Activation of c-Myc signaling leads to cancer growth and invasion in vitro and in vivo. The stability of c-Myc can also mediate drug resistance and radioresistance in cancers. The apoptosis inhibition and enhancing cell cycle progression are mediated by c-Myc overexpression. On the other hand, prostate cancer (PC) is the most common cancer in men and causes high death. The present review focuses on c-Myc signaling in PC. The c-Myc overexpression is in favor of PC growth and migration. Upon c-Myc inhibition, apoptosis and cell cycle arrest (G0/G1 phase) occur in PC cells. The c-Myc induces glycolysis in enhancing PC growth. Besides, stability and overexpression of c-Myc can mediate resistance of PC cells to chemotherapy and radiotherapy. The inhibition of c-Myc by both anti-tumor agents and genetic tools suppress PC progression. The miRNAs, lncRNAs, circRNAs and other factors such as PI3K/Akt can act as upstream regulator of c-Myc signaling. The c-Myc can function as independent prognostic and diagnostic factor in PC patients. The c-Myc upregulation is associated with reduced overall survival, clinical stage, lymph node metastasis and undesirable prognosis of PC patients. © 2022 Elsevier GmbHen_US
dc.identifier.citationFaskhoudi, M. A., Molaei, P., Sadrkhanloo, M., Orouei, S., Hashemi, M., Bokaie, S., ... & Gholami, M. H. (2022). Molecular landscape of c-Myc signaling in prostate cancer: A roadmap to clinical translation. Pathology-Research and Practice, 153851.en_US
dc.identifier.doi10.1016/j.prp.2022.153851en_US
dc.identifier.issn0344-0338en_US
dc.identifier.scopus2-s2.0-85126860539en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.prp.2022.153851
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2598
dc.identifier.volume233en_US
dc.identifier.wosWOS:000781694400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherElsevier GmbHen_US
dc.relation.ispartofPathology Research and Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiomarkeren_US
dc.subjectC-Mycen_US
dc.subjectDrug Resistanceen_US
dc.subjectNon-coding RNAsen_US
dc.subjectProstate Canceren_US
dc.titleMolecular landscape of c-Myc signaling in prostate cancer: A roadmap to clinical translationen_US
dc.typeReview Articleen_US

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