Rhabdomyosarcoma: Current Therapy, Challenges, and Future Approaches to Treatment Strategies

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dc.authoridZarepour, Atefeh/0000-0002-0347-5840
dc.authoridMadrakian, Tayyebeh/0000-0002-6876-7633
dc.authoridPecic, Stevan/0000-0002-3706-8768
dc.authoridZarrabi, Ali/0000-0003-0391-1769
dc.authoridGhavami, Saeid/0000-0001-5948-508X
dc.authoridMehrbod, Parvaneh/0000-0002-8391-9228
dc.authoridAhmadi, Mazaher/0000-0001-9969-170X
dc.authorwosidZarepour, Atefeh/AAH-9225-2020
dc.authorwosidMadrakian, Tayyebeh/C-2780-2018
dc.authorwosidPecic, Stevan/E-3578-2018
dc.authorwosidZarrabi, Ali/U-2602-2019
dc.authorwosid?os, Marek J/C-4038-2013
dc.authorwosidGhavami, Saeid/GLT-0606-2022
dc.authorwosidMehrbod, Parvaneh/I-4444-2017
dc.contributor.authorZarrabi, Ali
dc.contributor.authorPerrin, David
dc.contributor.authorKavoosi, Mahboubeh
dc.contributor.authorSommer, Micah
dc.contributor.authorSezen, Serap
dc.contributor.authorMehrbod, Parvaneh
dc.contributor.authorBhushan, Bhavya
dc.date.accessioned2024-05-19T14:38:58Z
dc.date.available2024-05-19T14:38:58Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractSimple Summary Rhabdomyosarcoma (RMS) is a rare pediatric sarcoma affecting skeletal muscle in children and young adults. It is responsible for 3% of all childhood malignant tumors and is the third most prevalent pediatric extracranial solid tumor. Despite advances in diagnostic and treatment methods and clinical trials to improve pediatric RMS survival rates, children with high-risk RMS and recurrent disease have 5-year survival rates of less than 30% and 17%, respectively. The cure rate remains low and the current RMS therapies continue to pose potential life-threatening toxicities, which can lead to lifelong morbidity. The treatment strategies for RMS include multi-agent chemotherapies after surgical resection with or without radiotherapy. Here, we focus on chemotherapy strategies and discuss the impact of apoptosis, autophagy, and the UPR that are involved in the chemotherapy response. Then, to screen future therapeutic approaches and promote muscle regeneration, we discuss in vivo mouse and zebrafish models and in vitro three-dimensional bioengineering models.Abstract Rhabdomyosarcoma is a rare cancer arising in skeletal muscle that typically impacts children and young adults. It is a worldwide challenge in child health as treatment outcomes for metastatic and recurrent disease still pose a major concern for both basic and clinical scientists. The treatment strategies for rhabdomyosarcoma include multi-agent chemotherapies after surgical resection with or without ionization radiotherapy. In this comprehensive review, we first provide a detailed clinical understanding of rhabdomyosarcoma including its classification and subtypes, diagnosis, and treatment strategies. Later, we focus on chemotherapy strategies for this childhood sarcoma and discuss the impact of three mechanisms that are involved in the chemotherapy response including apoptosis, macro-autophagy, and the unfolded protein response. Finally, we discuss in vivo mouse and zebrafish models and in vitro three-dimensional bioengineering models of rhabdomyosarcoma to screen future therapeutic approaches and promote muscle regeneration.en_US
dc.description.sponsorshipURGP [56977]; CHRIM [OG2023-24-05]en_US
dc.description.sponsorshipS.G. was supported by the URGP (56977) and CHRIM (OG2023-24-05) operating grant.en_US
dc.identifier.doi10.3390/cancers15215269
dc.identifier.issn2072-6694
dc.identifier.issue21en_US
dc.identifier.pmid37958442en_US
dc.identifier.scopus2-s2.0-85176726499en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org10.3390/cancers15215269
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4662
dc.identifier.volume15en_US
dc.identifier.wosWOS:001103177700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofCancersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAlveolar Rhabdomyosarcomaen_US
dc.subjectApoptosisen_US
dc.subjectAutophagyen_US
dc.subjectUnfolded Protein Responseen_US
dc.subjectBioengineeringen_US
dc.subjectTumor Stiffnessen_US
dc.titleRhabdomyosarcoma: Current Therapy, Challenges, and Future Approaches to Treatment Strategiesen_US
dc.typeReview Articleen_US

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