A low direct electrical signal attenuates oxidative stress and inflammation in septic rats

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dc.authoridHuri Bulut / 0000-0003-2706-9625en_US
dc.authorscopusidHuri Bulut / 57185264300
dc.authorwosidHuri Bulut / AAM-1432-2020
dc.contributor.authorÜstünova, Savaş
dc.contributor.authorHacıosmanoğlu, Ebru
dc.contributor.authorBulut, Huri
dc.contributor.authorElibol, Birsen
dc.contributor.authorKılıç, Aysu
dc.contributor.authorHekimoğlu, Rümeysa
dc.date.accessioned2021-09-13T07:42:26Z
dc.date.available2021-09-13T07:42:26Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractElectrical stimulation is proposed to exert an antimicrobial effect according to studies performed using bacterial and cell cultures. Therefore, we investigated the effects of electrification on inflammation in septic rats. Twenty-eight male Wistar albino rats were divided into 4 groups: healthy control (C), electrified healthy (E), sepsis (S), and electrified sepsis (SE) groups. Staphylococcus aureus (1 x 109 colonies) in 1 ml of medium was intraperitoneally injected into rats to produce a sepsis model. The rats in the E and SE groups were exposed to a low direct electrical signal (300 Hz and 2.5 volts) for 40 min and 1 and 6 h after bacterial infection. Immediately after the second electrical signal application, blood and tissue samples of the heart, lung, and liver were collected. An antibacterial effect of a low direct electrical signal was observed in the blood of rats. The effects of electrical signals on ameliorating changes in the histological structure of tissues, blood pH, gases, viscosity and cell count, activities of some important enzymes, oxidative stress parameters, inflammation and tissue apoptosis were observed in the SE group compared to the S group. Low direct electrical signal application exerts antibacterial, antioxidant, anti-inflammatory and antiapoptotic effects on septic rats due to the induction of electrolysis in body fluids without producing any tissue damage.en_US
dc.identifier.citationUstunova, S., Haciosmanoglu, E., Bulut, H., Elibol, B., Kilic, A., Hekimoglu, R., Tunc, S., Atmaca, R., Kaygusuz, I., Tunc, S., Tunc, G. B., & Meral, I. (2021). A low direct electrical signal attenuates oxidative stress and inflammation in septic rats. PloS one, 16(9), e0257177. https://doi.org/10.1371/journal.pone.0257177en_US
dc.identifier.doi10.1371/journal.pone.0257177en_US
dc.identifier.issue9en_US
dc.identifier.pmid34499695en_US
dc.identifier.scopus2-s2.0-85114690585en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0257177
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2046
dc.identifier.volume16en_US
dc.identifier.wosWOS:000733930800001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBulut, Huri
dc.language.isoenen_US
dc.publisherPMCen_US
dc.relation.ispartofPlos Oneen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleA low direct electrical signal attenuates oxidative stress and inflammation in septic ratsen_US
dc.typeArticleen_US

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