Investigation of serum vaspin, visfatin, chemerin and IL-18 levels in migraine patients

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dc.authorscopusidVugar Cafer / 57300542900
dc.authorwosidVugar Cafer / EOM-5613-2022
dc.contributor.authorDonder, Ahmet
dc.contributor.authorCafer, Vugar
dc.contributor.authorYilmaz, Ahmet
dc.contributor.authorAslanhan, Hamza
dc.contributor.authorArikanoglu, Adalet
dc.date.accessioned2021-10-27T06:01:06Z
dc.date.available2021-10-27T06:01:06Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Hastaneen_US
dc.description.abstractBackground: Migraines are headaches caused by changes in the trigeminovascular metabolic pathway. Migraine headache attacks are associated with neurovascular inflammation, but their pathophysiological mechanisms have not been fully explained. Objective: To investigate the relationship between serum vaspin, visfatin, chemerin and interleukin-18 (IL-18) levels and the frequency of attacks in migraine headache. Methods: Three groups were established: migraine with aura (n = 50), migraine without aura (n = 50) and control group (n = 50). The migraine diagnosis was made in accordance with the International Classification of Headache Disorders-III beta diagnostic criteria. The analyses on serum vaspin, visfatin, chemerin and IL-18 levels were performed using the enzyme-linked immunosorbent assay method. Results: The serum vaspin, visfatin, chemerin and IL-18 levels were found to be significantly higher in the migraine patients than in the control group (p < 0.01). No statistically signi?cant differences in serum vaspin, visfatin, chemerin and IL-18 levels were found among the migraine patients during attacks or in the interictal period (p>0.05). The serum visfatin and chemerin levels of the migraine patients were positively correlated with their serum IL-18 levels (p < 0.01), while their serum chemerin and visfatin levels were positively correlated with their serum vaspin levels (p < 0.05). Conclusions: This study showed that these biomarkers may be related to migraine pathogenesis. Nonetheless, we believe that more comprehensive studies are needed in order to further understand the role of vaspin, visfatin, chemerin and IL-18 levels in the pathophysiology of migraine headaches.en_US
dc.identifier.citationDönder, A., Cafer, V., Yilmaz, A., Aslanhan, H., & Arikanoğlu, A. (2021). Investigation of serum vaspin, visfatin, chemerin and IL-18 levels in migraine patients. Arquivos de neuro-psiquiatria, 79(9), 789–794. https://doi.org/10.1590/0004-282X-ANP-2020-0425en_US
dc.identifier.doi10.1590/0004-282X-ANP-2020-0425en_US
dc.identifier.endpage794en_US
dc.identifier.issue9en_US
dc.identifier.pmid34669816en_US
dc.identifier.scopus2-s2.0-85117400052en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage789en_US
dc.identifier.urihttps://doi.org/10.1590/0004-282X-ANP-2020-0425
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2188
dc.identifier.volume79en_US
dc.identifier.wosWOS:000727387000006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorCafer, Vugar
dc.language.isoenen_US
dc.publisherSciELOen_US
dc.relation.ispartofArq Neuropsiquiatr.en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChimerin 1en_US
dc.subjectInterleukin-18en_US
dc.subjectInflammationen_US
dc.subjectMigraine Without Auraen_US
dc.subjectPathogenesis Homeopathicen_US
dc.subjectVaspinen_US
dc.subjectNicotinamide Phosphoribosyltransferaseen_US
dc.titleInvestigation of serum vaspin, visfatin, chemerin and IL-18 levels in migraine patientsen_US
dc.typeArticleen_US

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