(Nano)platforms in breast cancer therapy: Drug/gene delivery, advanced nanocarriers and immunotherapy

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dc.authoridRabiee, Navid/0000-0002-6945-8541
dc.authoridKarimi-maleh, Hassan/0000-0002-1027-481X
dc.authoridErtas, Yavuz Nuri/0000-0002-6791-7484
dc.authoridAshrafizadeh, Milad/0000-0001-6605-822X
dc.authoridNazarzadeh Zare, Ehsan/0000-0002-0446-4385
dc.authorwosidRabiee, Navid/K-4407-2019
dc.authorwosidHashemi, Mehrdad/JHT-4661-2023
dc.authorwosidKarimi-maleh, Hassan/N-1727-2019
dc.authorwosidMirzaei, Sepideh/AAB-1637-2022
dc.authorwosidErtas, Yavuz Nuri/ABH-8904-2020
dc.authorwosidAshrafizadeh, Milad/JGC-9775-2023
dc.contributor.authorAshrafizadeh, Milad
dc.contributor.authorZarrabi, Ali
dc.contributor.authorBigham, Ashkan
dc.contributor.authorTaheriazam, Afshin
dc.contributor.authorSaghari, Yalda
dc.contributor.authorMirzaei, Sepideh
dc.contributor.authorHashemi, Mehrdad
dc.date.accessioned2024-05-19T14:39:36Z
dc.date.available2024-05-19T14:39:36Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBreast cancer is the most malignant tumor in women, and there is no absolute cure for it. Although treatment modalities including surgery, chemotherapy, and radiotherapy are utilized for breast cancer, it is still a life-threatening disease for humans. Nanomedicine has provided a new opportunity in breast cancer treatment, which is the focus of the current study. The nanocarriers deliver chemotherapeutic agents and natural products, both of which increase cytotoxicity against breast tumor cells and prevent the development of drug resistance. The efficacy of gene therapy is boosted by nanoparticles and the delivery of CRISPR/Cas9, Noncoding RNAs, and RNAi, promoting their potential for gene expression regulation. The drug and gene codelivery by nanoparticles can exert a synergistic impact on breast tumors and enhance cellular uptake via endocytosis. Nanostructures are able to induce photothermal and photodynamic therapy for breast tumor ablation via cell death induction. The nanoparticles can provide tumor microenvironment remodeling and repolarization of macrophages for antitumor immunity. The stimuli-responsive nanocarriers, including pH-, redox-, and light-sensitive, can mediate targeted suppression of breast tumors. Besides, nanoparticles can provide a diagnosis of breast cancer and detect biomarkers. Various kinds of nanoparticles have been employed for breast cancer therapy, including carbon-, lipid-, polymeric- and metal-based nanostructures, which are different in terms of biocompatibility and delivery efficiency.en_US
dc.description.sponsorshipKey R&D in Hainan Province [ZDYF2020123]; Key R&D projects in Hainan Province [ZDYF2023SHFZ145]; National key RD plan [2020YFC2004706]en_US
dc.description.sponsorshipKey R&D in Hainan Province, Grant/Award Number: ZDYF2020123; Key R&D projects in Hainan Province, Grant/Award Number: ZDYF2023SHFZ145;National key R&D plan, Grant/Award Number:2020YFC2004706en_US
dc.identifier.doi10.1002/med.21971
dc.identifier.endpage2176en_US
dc.identifier.issn0198-6325
dc.identifier.issn1098-1128
dc.identifier.issue6en_US
dc.identifier.pmid37165896en_US
dc.identifier.scopus2-s2.0-85159058380en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2115en_US
dc.identifier.urihttps://doi.org10.1002/med.21971
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4814
dc.identifier.volume43en_US
dc.identifier.wosWOS:000985385900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofMedicinal Research Reviewsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectBreast Canceren_US
dc.subjectCancer Therapyen_US
dc.subjectClinical Applicationen_US
dc.subjectNanotechnologyen_US
dc.subjectStimuli-Responsive Nanocarriersen_US
dc.title(Nano)platforms in breast cancer therapy: Drug/gene delivery, advanced nanocarriers and immunotherapyen_US
dc.typeReview Articleen_US

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