A structural and resting-state functional connectivity investigation of the pulvinar in elderly individuals and Alzheimer's disease patients

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dc.authoridSevilay Ayyıldız / 0000-0001-6870-8177en_US
dc.authoridBehçet Ayyıldız / 0000-0003-1750-4099en_US
dc.authorscopusidBehçet Ayyıldız / 57269886300en_US
dc.authorscopusidSevilay Ayyıldız / 57807205200en_US
dc.authorwosidBehçet Ayyıldız / GNX-7812-2022en_US
dc.authorwosidSevilay Ayyıldız / GNY-0869-2022en_US
dc.contributor.authorVelioğlu, Halil Aziz
dc.contributor.authorAyyıldız, Behçet
dc.contributor.authorAyyıldız, Sevilay
dc.contributor.authorSütçübaşı, Bernis
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorBayraktaroğlu, Zübeyir
dc.contributor.authorYuluğ, Burak
dc.date.accessioned2023-01-26T10:47:25Z
dc.date.available2023-01-26T10:47:25Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractIn Alzheimer's disease (AD), structural and functional changes in the brain may give rise to disruption of specific cognitive functions. The aim of this study is to investigate the functional connectivity alterations in the pulvinar's subdivisions and total pulvinar voxel-based morphometry (VBM) changes in individuals with AD and healthy controls. A seed-based functional connectivity analysis was applied to the anterior, inferior, lateral, and medial pulvinar in each hemisphere. Furthermore, VBM analysis was carried out to compare gray matter (GM) volume differences in the pulvinar and thalamus between the two groups. Connectivity analysis revealed that the pulvinar subdivisions had decreased connectivity in individuals with AD. In addition, the pulvinar and thalamus in each hemisphere were significantly smaller in the AD group. The pulvinar may have a role in AD-related cognitive impairments and the intrinsic connectivity network changes and GM loss in pulvinar subdivisions suggest the cognitive deterioration occurring in those with AD. Highlights: The pulvinar may play a role in pathophysiology of cognitive impairments in those with Alzheimer's disease (AD). Decreased structural volume and functional connectivity were found in patients with AD. The inferior pulvinar is functionally the most affected subdivision by AD compared to the others. © 2022 the Alzheimer's Association.en_US
dc.identifier.citationVelioglu, H. A., Ayyildiz, B., Ayyildiz, S., Sutcubasi, B., Hanoglu, L., Bayraktaroglu, Z., & Yulug, B. (2022). A structural and resting‐state functional connectivity investigation of the pulvinar in elderly individuals and Alzheimer's disease patients. Alzheimer's & Dementia.en_US
dc.identifier.doi10.1002/alz.12850en_US
dc.identifier.issn1552-5260en_US
dc.identifier.issn1552-5279en_US
dc.identifier.pmid36576157en_US
dc.identifier.scopus2-s2.0-85145302962en_US
dc.identifier.urihttp://dx.doi.org/10.1002/alz.12850
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3829
dc.identifier.wosWOS:000904940000001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorAyyıldız, Sevilay
dc.institutionauthorAyyıldız, Behçet
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofALZHEIMERS & DEMENTIAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlzheimer's Diseaseen_US
dc.subjectCognitive Impairmenten_US
dc.subjectFunctional Magnetic Resonance Imagingen_US
dc.subjectPulvinaren_US
dc.subjectThalamusen_US
dc.subjectVoxel-Based Morphometryen_US
dc.titleA structural and resting-state functional connectivity investigation of the pulvinar in elderly individuals and Alzheimer's disease patientsen_US
dc.typeArticleen_US

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