Targeting autophagy, oxidative stress, and ER stress for neurodegenerative diseases treatment
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Tarih
2022
Dergi Başlığı
Dergi ISSN
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info:eu-repo/semantics/closedAccess
Özet
Protein homeostasis is a vital process for cell function and, therefore, disruption of the molecular mechanisms involved in this process, such as autophagy, may contribute to neurodegenerative diseases (NDs). Apart from autophagy disruption, excess oxidative stress and endoplasmic reticulum (ER) stress are additional main molecular mechanisms underlying neurodegeneration, leading to protein aggregation, and mitochondrial dysfunction. Notably, these primary molecular processes are interconnected pathways which have synergistic effects on each other. Therefore, we propose that targeting of the crosstalk between autophagy, oxidative stress and ER stress simultaneously may play a critical role in healing NDs. NeuroNanoTechnology, as a revolutionized approach, in combination with an in-silico strategy, holds great promise for developing de-novo structures for targeting and modulating neuro-molecular pathways. Accordingly, this review outlines the contributions of autophagy, oxidative stress, and ER stress in neurodegenerative conditions along with a particular focus on the crosstalk among these pathways. Furthermore, we provide a comprehensive discussion on the potential of nanomaterials to target this crosstalk and suggest this potential as a promising opportunity in neuroprotection.
Açıklama
Anahtar Kelimeler
Autophagy, Endoplasmic Reticulum Stress, Nanotechnology, Neurodegeneration, Oxidative Stress
Kaynak
J Control Release
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
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Sayı
Künye
Esmaeili Y, Yarjanli Z, Pakniya F, Bidram E, Los MJ, Eshraghi M, Klionsky DJ, Ghavami S, Zarrabi A. Targeting autophagy, oxidative stress, and ER stress for neurodegenerative diseases treatment. J Control Release. 2022 Mar 3:S0168-3659(22)00111-0. doi:
