Anti-microbial, anti-oxidant and wound healing capabilities of Aloe vera-incorporated hybrid nanoflowers
dc.authorid | Haciosmanoglu Aldogan, Ebru/0000-0001-9559-4515 | |
dc.authorid | ÖZDEMİR, NALAN/0000-0002-8930-5198 | |
dc.authorid | Altinkaynak, Cevahir/0000-0003-0082-8521 | |
dc.authorid | ekremoglu, murat/0000-0002-8355-7052 | |
dc.authorid | HACIOGLU, MAYRAM/0000-0003-0823-631X | |
dc.authorwosid | ekremoglu, murat/AGH-3509-2022 | |
dc.authorwosid | Haciosmanoglu Aldogan, Ebru/AAK-3496-2020 | |
dc.authorwosid | ÖZDEMİR, NALAN/AAL-7083-2021 | |
dc.authorwosid | ekremoglu, murat/AGI-0385-2022 | |
dc.contributor.author | Altinkaynak, Cevahir | |
dc.contributor.author | Haciosmanoglu, Ebru | |
dc.contributor.author | Ekremoglu, Murat | |
dc.contributor.author | Hacioglu, Mayram | |
dc.contributor.author | Ozdemir, Nalan | |
dc.date.accessioned | 2024-05-19T14:42:32Z | |
dc.date.available | 2024-05-19T14:42:32Z | |
dc.date.issued | 2023 | |
dc.department | İstinye Üniversitesi | en_US |
dc.description.abstract | The active ingredients of Aloe vera have attracted attention for their potential use in nanotechnology-based medical applications and biomaterial production. It has many therapeutic applications in modern world. This study used Aloe vera extract in different concentrations to synthesize Aloe vera-incorporated hybrid nanoflowers (AV-Nfs). The most uniform morphology in the nanoflowers obtained was at a concentration of 2 mL. The AV-Nfs were well characterized by scanning electron microscopy, X-ray spectroscopy, Fourier transform infrared spectroscopy, and X-ray diffraction (XRD). The highest peroxidase-mimicking activity of the components was 1.488 EU/mg at 60 degrees C and pH 6. The DPPH assay determined the antioxidant activity of the components and the MTT assay tested on CCD-1072Sk fibroblast cell line determined the effect of AV-Nfs on cell proliferation. Separate treatment of AV-Nfs with Cu3(PO4)2 center dot 3H2O significantly increased cell proliferation according to free Aloe vera and CuSO4. In vitro wound healing results showed that AV-Nfs could significantly close wounds compared to free Aloe vera. In this study, AV-Nfs showed antimicrobial activity against Staphylococcus epidermidis, Enterococcus faecalis, Escherichia coli and Klebsiella pneumoniae at minimum inhibitory concentration of 625 mg/mL, suggesting that AV-Nfs may be used in wound healing applications with enhanced bio-logical properties. AV-Nfs showed no activity against the yeast Candida albicans.(c) 2023, The Society for Biotechnology, Japan. All rights reserved. | en_US |
dc.description.sponsorship | Scientific Research Projects Committee of Nevsehir Haci Bektas Veli University [CBAP21F4] | en_US |
dc.description.sponsorship | This study is supported by the Scientific Research Projects Committee of Nevsehir Haci Bektas Veli University (Project No: CBAP21F4) . We declare there are no conflicts of interest. C.A., E.H. and M.E. conceived the original idea and developed it. C.A. super- vised the project. All authors wrote, read and approved the final manuscript. | en_US |
dc.identifier.doi | 10.1016/j.jbiosc.2023.01.004 | |
dc.identifier.endpage | 330 | en_US |
dc.identifier.issn | 1389-1723 | |
dc.identifier.issn | 1347-4421 | |
dc.identifier.issue | 4 | en_US |
dc.identifier.pmid | 36806412 | en_US |
dc.identifier.scopus | 2-s2.0-85148342789 | en_US |
dc.identifier.scopusquality | Q2 | en_US |
dc.identifier.startpage | 321 | en_US |
dc.identifier.uri | https://doi.org10.1016/j.jbiosc.2023.01.004 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12713/5253 | |
dc.identifier.volume | 135 | en_US |
dc.identifier.wos | WOS:000962145700001 | en_US |
dc.identifier.wosquality | N/A | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.language.iso | en | en_US |
dc.publisher | Soc Bioscience Bioengineering Japan | en_US |
dc.relation.ispartof | Journal of Bioscience and Bioengineering | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.snmz | 20240519_ka | en_US |
dc.subject | Hybrid Nanoflower | en_US |
dc.subject | Aloe Vera | en_US |
dc.subject | Wound Healing | en_US |
dc.subject | Anti-Microbial | en_US |
dc.subject | Anti-Oxidant | en_US |
dc.title | Anti-microbial, anti-oxidant and wound healing capabilities of Aloe vera-incorporated hybrid nanoflowers | en_US |
dc.type | Article | en_US |