Anti-microbial, anti-oxidant and wound healing capabilities of Aloe vera-incorporated hybrid nanoflowers

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dc.authoridHaciosmanoglu Aldogan, Ebru/0000-0001-9559-4515
dc.authoridÖZDEMİR, NALAN/0000-0002-8930-5198
dc.authoridAltinkaynak, Cevahir/0000-0003-0082-8521
dc.authoridekremoglu, murat/0000-0002-8355-7052
dc.authoridHACIOGLU, MAYRAM/0000-0003-0823-631X
dc.authorwosidekremoglu, murat/AGH-3509-2022
dc.authorwosidHaciosmanoglu Aldogan, Ebru/AAK-3496-2020
dc.authorwosidÖZDEMİR, NALAN/AAL-7083-2021
dc.authorwosidekremoglu, murat/AGI-0385-2022
dc.contributor.authorAltinkaynak, Cevahir
dc.contributor.authorHaciosmanoglu, Ebru
dc.contributor.authorEkremoglu, Murat
dc.contributor.authorHacioglu, Mayram
dc.contributor.authorOzdemir, Nalan
dc.date.accessioned2024-05-19T14:42:32Z
dc.date.available2024-05-19T14:42:32Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractThe active ingredients of Aloe vera have attracted attention for their potential use in nanotechnology-based medical applications and biomaterial production. It has many therapeutic applications in modern world. This study used Aloe vera extract in different concentrations to synthesize Aloe vera-incorporated hybrid nanoflowers (AV-Nfs). The most uniform morphology in the nanoflowers obtained was at a concentration of 2 mL. The AV-Nfs were well characterized by scanning electron microscopy, X-ray spectroscopy, Fourier transform infrared spectroscopy, and X-ray diffraction (XRD). The highest peroxidase-mimicking activity of the components was 1.488 EU/mg at 60 degrees C and pH 6. The DPPH assay determined the antioxidant activity of the components and the MTT assay tested on CCD-1072Sk fibroblast cell line determined the effect of AV-Nfs on cell proliferation. Separate treatment of AV-Nfs with Cu3(PO4)2 center dot 3H2O significantly increased cell proliferation according to free Aloe vera and CuSO4. In vitro wound healing results showed that AV-Nfs could significantly close wounds compared to free Aloe vera. In this study, AV-Nfs showed antimicrobial activity against Staphylococcus epidermidis, Enterococcus faecalis, Escherichia coli and Klebsiella pneumoniae at minimum inhibitory concentration of 625 mg/mL, suggesting that AV-Nfs may be used in wound healing applications with enhanced bio-logical properties. AV-Nfs showed no activity against the yeast Candida albicans.(c) 2023, The Society for Biotechnology, Japan. All rights reserved.en_US
dc.description.sponsorshipScientific Research Projects Committee of Nevsehir Haci Bektas Veli University [CBAP21F4]en_US
dc.description.sponsorshipThis study is supported by the Scientific Research Projects Committee of Nevsehir Haci Bektas Veli University (Project No: CBAP21F4) . We declare there are no conflicts of interest. C.A., E.H. and M.E. conceived the original idea and developed it. C.A. super- vised the project. All authors wrote, read and approved the final manuscript.en_US
dc.identifier.doi10.1016/j.jbiosc.2023.01.004
dc.identifier.endpage330en_US
dc.identifier.issn1389-1723
dc.identifier.issn1347-4421
dc.identifier.issue4en_US
dc.identifier.pmid36806412en_US
dc.identifier.scopus2-s2.0-85148342789en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage321en_US
dc.identifier.urihttps://doi.org10.1016/j.jbiosc.2023.01.004
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5253
dc.identifier.volume135en_US
dc.identifier.wosWOS:000962145700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSoc Bioscience Bioengineering Japanen_US
dc.relation.ispartofJournal of Bioscience and Bioengineeringen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectHybrid Nanofloweren_US
dc.subjectAloe Veraen_US
dc.subjectWound Healingen_US
dc.subjectAnti-Microbialen_US
dc.subjectAnti-Oxidanten_US
dc.titleAnti-microbial, anti-oxidant and wound healing capabilities of Aloe vera-incorporated hybrid nanoflowersen_US
dc.typeArticleen_US

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