Cortisol response to stress in schizophrenia: associations with oxytocin, social support and social functioning

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dc.authoridGökçer Eskikurt / 0000-0003-4898-8639en_US
dc.authorscopusidGökçer Eskikurt / 55629841500
dc.authorwosidGökçer Eskikurt / J-4772-2018
dc.contributor.authorTaş, Cumhur
dc.contributor.authorBrown, Elliot C.
dc.contributor.authorEskikurt, Gökçer
dc.contributor.authorIrmak, Sezen
dc.contributor.authorAydın, Orkun
dc.contributor.authorEsen-Danacı, Aysen
dc.contributor.authorBruene, Martin
dc.date.accessioned2020-08-30T20:07:12Z
dc.date.available2020-08-30T20:07:12Z
dc.date.issued2018
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractPrevious studies reported attenuated cortisol reactivity as one explanation for poor social functioning in schizophrenia. Recent research has demonstrated that both glucocorticoid and oxytocin systems are central to stress regulation. Here, we studied the associations between basal oxytocin, stress-induced cortisol levels, and social functioning and social support in schizophrenia. A mock job interview was used as an ecologically-valid social stressor in 32 schizophrenia patients. Blood samples were taken before and after stress induction to assess basal oxytocin and cortisol levels. In addition social functioning and social support scales were collected. Patients were divided into cortisol responders and non-responders according to percentage change following stress induction. Our findings revealed a possible subgroup of patients who did not exhibit attenuated cortisol responses. Importantly, cortisol responders had generally better social functioning, but perceived social support was not different between groups. There was also no evidence of a relationship between cortisol and oxytocin. This study highlights the heterogeneity of cortisol responses to stress in a schizophrenia population, and the importance of the relationship between social functioning and cortisol reactivity. These findings could be relevant when considering therapeutic interventions that manipulate endocrinology in order to improve real-world functioning.en_US
dc.description.sponsorshipRuhr University Research School - TUBITAK (The Scientific and Technological Research Council of Turkey) foreign researcher fellowshipen_US
dc.description.sponsorshipRuhr University Research School funded the costs for the biochemical kits. Dr Brown was funded by a TUBITAK (The Scientific and Technological Research Council of Turkey) foreign researcher fellowship for the partial duration of this study. There are no conflicts of interest.en_US
dc.identifier.citationTas, C., Brown, E. C., Eskikurt, G., Irmak, S., Aydın, O., Esen-Danaci, A., & Brüne, M. (2018). Cortisol response to stress in schizophrenia: associations with oxytocin, social support and social functioning. Psychiatry research, 270, 1047-1052.en_US
dc.identifier.doi10.1016/j.psychres.2018.05.011en_US
dc.identifier.endpage1052en_US
dc.identifier.issn0165-1781en_US
dc.identifier.pmid29960725en_US
dc.identifier.scopus2-s2.0-85049053522en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1047en_US
dc.identifier.urihttps://doi.org/10.1016/j.psychres.2018.05.011
dc.identifier.urihttps://hdl.handle.net/20.500.12713/717
dc.identifier.volume270en_US
dc.identifier.wosWOS:000454972600148en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorEskikurt, Gökçeren_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofPsychiatry Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCortisolen_US
dc.subjectOxytocinen_US
dc.subjectStressen_US
dc.subjectSchizophreniaen_US
dc.subjectSocial Functioningen_US
dc.subjectSocial Supporten_US
dc.titleCortisol response to stress in schizophrenia: associations with oxytocin, social support and social functioningen_US
dc.typeArticleen_US

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