Prognostic importance of microvessel density, VEGF expression and perineural invasion in laryngeal cancer treated with adjuvant radiotherapy

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dc.authoridGörkem Türkkan / 0000-0002-9084-2599en_US
dc.authorscopusidGörkem Türkkan / 56841633300
dc.authorwosidGörkem Türkkan / E-7048-2017en_US
dc.contributor.authorHarmankaya, Ilknur
dc.contributor.authorCaloglu, Vuslat Yurut
dc.contributor.authorTastekin, Ebru
dc.contributor.authorTürkkan, Görkem
dc.contributor.authorCaloglu, Murat
dc.contributor.authorUzal,Cem
dc.date.accessioned2022-08-02T06:11:01Z
dc.date.available2022-08-02T06:11:01Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground and aims: We aimed to investigate the prognostic importance of the microvessel density (MVD) value, the vascular endothelial growth factor (VEGF) expression, and the presence of perineural invasion (PNI) in laryngeal cancer (LSCC) patients. Methods: Pathological specimens of 62 LSCC patients were assessed for the evaluation of the MVD value, the VEGF expression level, and the presence of PNI of the tumors. The tumor characteristics and prognostic effects of these parameters on local control (LC) and overall survival (OS) were analyzed. Statistical analysis: Descriptive analyses were done using frequencies for the demographic variables. The survival estimates were calculated by the Kaplan-Meier survival curves. The effects of the parameters on LC and OS were investigated by using the log-rank test comparing the survival rates. Cox regression analysis was used for multivariable analysis. Results: The 5-year LC and OS rates of the 62 LSCC patients were 64.5 and 53.9%, respectively. Twenty-two patients (35.5%) had PNI and the frequency of PNI was higher in the patients with a high-grade disease (P = 0.01). The MVD value was higher in the tumors of older patients (P = 0.035) and was correlated with the VEGF expression (P = 0.009). A higher tumor grade was related to a higher VEGF expression (P = 0.01) and the increase in the VEGF expression was associated with a significant decrease in the OS (P = 0.03). Conclusion: The VEGF expression, the MVD value, and the presence of PNI had no prognostic significance on the LC in the LSCC patients while only the VEGF expression was associated with the OS.en_US
dc.identifier.citationHarmankaya I, Çaloğlu VY, Taştekin E, Türkkan G, Çaloğlu M, Uzal C. Prognostic importance of microvessel density, VEGF expression and perineural invasion in laryngeal cancer treated with adjuvant radiotherapy. Indian J Pathol Microbiol. 2022 Jul-Sep;65(3):521-526. doi: 10.4103/ijpm.ijpm_655_21. PMID: 35900477.en_US
dc.identifier.doi10.4103/ijpm.ijpm_655_21en_US
dc.identifier.endpage526en_US
dc.identifier.issn0377-4929en_US
dc.identifier.issue3en_US
dc.identifier.pmid35900477en_US
dc.identifier.scopus2-s2.0-85135379356en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage521en_US
dc.identifier.urihttps://doi.org/10.4103/ijpm.ijpm_655_21
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3062
dc.identifier.volume65en_US
dc.identifier.wosWOS:000935829800002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTürkkan, Görkem
dc.language.isoenen_US
dc.publisherIndian Association of Pathologists & Microbiologistsen_US
dc.relation.ispartofIndian Association of Pathologists & Microbiologistsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMicrovessel Densityen_US
dc.subjectPerineural Invasionen_US
dc.subjectVascular Endothelialen_US
dc.subjectGrowth Factor Expressionen_US
dc.titlePrognostic importance of microvessel density, VEGF expression and perineural invasion in laryngeal cancer treated with adjuvant radiotherapyen_US
dc.typeArticleen_US

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