Changes in various hormone levels in The rabbit traumatic facial nerve injury model

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dc.authoridZeliha Kapusuz Gencer / 0000-0003-4707-5862
dc.authoridMuzaffer Gencer / 0000-0002-3324-5106
dc.authorscopusidMuzaffer Gencer / 57218915766
dc.authorwosidMuzaffer Gencer / EWA-8922-2022
dc.contributor.authorKapusuz Gencer, Zeliha
dc.contributor.authorÖzkiriş, Mahmut
dc.contributor.authorGencer, Muzaffer
dc.contributor.authorGöçmen, Ayşe Yeşim
dc.contributor.authorDağlıoğlu, Yusuf Kenan
dc.date.accessioned2020-08-30T20:07:26Z
dc.date.available2020-08-30T20:07:26Z
dc.date.issued2018
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives: We aimed to look into potential associations between specific biomarkers and trauma to Cranial Nerve VII (CNVII) in a rabbit model, focusing on whether endocrine studies have potential as biomarkers in this context. Methods: 30 adult New Zealand rabbits with intact facial muscles were used for the research. Each animal underwent identical surgery by the same surgeon. The facial nerve divisions were exposed by incising below the level of the mandible. After dissection of the skin and subcutaneous layers, the buccal division of CNVII was located with the nerve stimulator and microscopic dissection and a section of nerve 10mm long was excised in each case from the buccal branch of CNVII. Blood samples were drawn 8 weeks and 12 weeks after nerve injury had been surgically induced. The samples from day 1, week 4 and week 8 were tested for the following levels: Testosterone, oestrogen, progesterone, free T3 and T4, Cancer antigen 19-9 (Ca19-9), folate, TPSA, FPSA, FSH, LH, CA15.3, CAE, AFP and prolactin. Results: The levels of free T3 and T4 as well as testosterone, were down at 4th week, but at 8 weeks each had increased. Ca19-9 levels were also above the baseline. At 4 weeks, whilst oestrogen had markedly risen, progesterone had fallen. The statistical significance of the change in levels of free T3 and T4, testosterone, oestrogen, progesterone and FPSA was evaluated. For the group of animals with induced paralysis, the association between the lesion and testosterone, oestrogen, progesterone, free T3 and T4, Ca19-9, and folate levels were strong and at the level of statistical significance. Conclusion: There were statistically significant alterations in the serum levels of free T3 and T4, testosterone, oestrogen, progesterone and FPSA at the 4 and 8 week intervals post surgically-induced CNVII injury. It is likely that rabbit pathophysiology resembles human pathophysiology in nervous injury, hence these six biomarkers may be of value in managing trauma or idiopathic degeneration of CNVII in humans. The authors hope this study will pave the way for future research in this area.en_US
dc.identifier.citationKapusuz, Z., ÖZKIRIŞ, M., Gencer, M., GÖÇMEN, A. Y., & DAĞLIOĞLU, Y. K. (2018). Changes In Various Hormone Levels In The Rabbit Traumatic Facial Nerve Injury Model. ENT Updates, 8(2), 88-92.en_US
dc.identifier.doi10.32448/entupdates.45899en_US
dc.identifier.endpage92en_US
dc.identifier.issn2149-7109en_US
dc.identifier.issn2149-6498en_US
dc.identifier.issue2en_US
dc.identifier.startpage88en_US
dc.identifier.urihttps://doi.org/10.32448/entupdates.45899
dc.identifier.urihttps://hdl.handle.net/20.500.12713/766
dc.identifier.volume8en_US
dc.identifier.wosWOS:000493730200005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorKapusuz Gencer, Zelihaen_US
dc.institutionauthorGencer, Muzaffer
dc.language.isoenen_US
dc.publisherDeomed Publ, Istanbulen_US
dc.relation.ispartofEnt Updatesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInjuryen_US
dc.subjectFacial Nerveen_US
dc.subjectHormonesen_US
dc.titleChanges in various hormone levels in The rabbit traumatic facial nerve injury modelen_US
dc.typeArticleen_US

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