Comparison of the diagnostic utility of manual screening and the thinprep imaging system in liquid-based cervical cytology

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dc.authoridNusret Erdoğan / 0000-0002-0333-8600en_US
dc.authorscopusidNusret Erdoğan / 7004283152
dc.authorwosidNusret Erdoğan / K-6413-2018
dc.contributor.authorÖzcan, Zühal
dc.contributor.authorKımıloğlu, Elife
dc.contributor.authorAkyıldız İğdem, Ayşenur
dc.contributor.authorErdoğan, Nusret
dc.date.accessioned2020-08-30T20:01:35Z
dc.date.available2020-08-30T20:01:35Z
dc.date.issued2020
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: To compare the diagnostic results of the ThinPrep manual method (TPMM) and ThinPrep automated method (TPAM) in liquid-based cytology and present the advantages and disadvantages of both methods. Material and Method: A total of 1.500 randomized ThinPrep Pap tests that were screened manually and archived in 2015 were reviewed by a blinded researcher manually and by the ThinPrep automatic method. Results: There was a 83.3% increase in the detection of ASCUS (Atypical squamous cells of undetermined significance) with the TPAM compared to the TPMM, and with respect to the reference results, the accuracy was higher for the TPAM than for the TPMM. We also noted a 33.3% increase in the rate of LSIL (Low grade squamous intraepithelial lesion) and 20% increase in the rate of HSIL (High grade squamous intraepithelial lesion) by the TPAM. Concordance was best between the TPAM and reference cytologic diagnoses. The sensitivity was higher for the TPAM and the specificity was similar for both methods. The false positive rate was higher for the TPAM than the TPMM but the false negative rate was higher for the TPMM. We determined a 30% gain in screening time per smear by the TPAM. However, rejection of many samples by the system, especially because of air bubbles, was a limitation of the TPAM. Conclusion: The TPAM has advantages over the TPMM as well as disadvantages such as limiting features and a high false positive rate. The TPAM should be supported by the manual method to decrease the false positive rate. © 2020, Federation of Turkish Pathology Societies. All rights reserved.en_US
dc.identifier.citationÖzcan, Z., Kimiloğlu, E., Iğdem, A. A., & Erdoğan, N. (2020). Comparison of the diagnostic utility of manual screening and the thinprep imaging system in liquid-based cervical cytology. Turkish Journal of Pathology. doi, 10.en_US
dc.identifier.doi10.5146/tjpath.2019.01473en_US
dc.identifier.endpage141en_US
dc.identifier.issn1018-5615en_US
dc.identifier.issue2en_US
dc.identifier.pmid31769500en_US
dc.identifier.scopus2-s2.0-85084128373en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage135en_US
dc.identifier.trdizinid372112en_US
dc.identifier.urihttps://doi.org/10.5146/tjpath.2019.01473
dc.identifier.urihttps://hdl.handle.net/20.500.12713/299
dc.identifier.volume36en_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorErdoğan, Nusreten_US
dc.language.isoenen_US
dc.publisherFederation of Turkish Pathology Societiesen_US
dc.relation.ispartofTurk Patoloji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLiquid-Based Cervical Cytologyen_US
dc.subjectManual Methoden_US
dc.subjectThinprep Imaging Systemen_US
dc.titleComparison of the diagnostic utility of manual screening and the thinprep imaging system in liquid-based cervical cytologyen_US
dc.typeArticleen_US

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