Non-coding RNA-Mediated N6-Methyladenosine (m6A) deposition: A pivotal regulator of cancer, impacting key signaling pathways in carcinogenesis and therapy response

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dc.authoridEntezari, Maliheh/0000-0003-4191-3351
dc.authoridHashemi, Mehrdad/0000-0003-0627-6991
dc.authoridKhorrami, Ramin/0000-0001-5385-7137
dc.authorwosidEntezari, Maliheh/AAO-5684-2021
dc.authorwosidHashemi, Mehrdad/AAO-5675-2021
dc.authorwosidKhorrami, Ramin/JCO-7588-2023
dc.contributor.authorHashemi, Mehrdad
dc.contributor.authorDaneii, Pouria
dc.contributor.authorZandieh, Mohammad Arad
dc.contributor.authorRaesi, Rasoul
dc.contributor.authorZahmatkesh, Neda
dc.contributor.authorBayat, Mehrsa
dc.contributor.authorAbuelrub, Anwar
dc.date.accessioned2024-05-19T14:43:06Z
dc.date.available2024-05-19T14:43:06Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractThe emergence of RNA modifications has recently been considered as critical post-transcriptional regulations which governed gene expression. N6-methyladenosine (m6A) modification is the most abundant type of RNA modification which is mediated by three distinct classes of proteins called m6A writers, readers, and erasers. Accumulating evidence has been made in understanding the role of m6A modification of non-coding RNAs (ncRNAs) in cancer. Importantly, aberrant expression of ncRNAs and m6A regulators has been elucidated in various cancers. As the key role of ncRNAs in regulation of cancer hallmarks is well accepted now, it could be accepted that m6A modification of ncRNAs could affect cancer progression. The present review intended to discuss the latest knowledge and importance of m6A epigenetic regulation of ncRNAs including mircoRNAs, long non-coding RNAs, and circular RNAs, and their interaction in the context of cancer. Moreover, the current insight into the underlying mechanisms of therapy resistance and also immune response and escape mediated by m6A regulators and ncRNAs are discussed.en_US
dc.identifier.doi10.1016/j.ncrna.2023.11.005
dc.identifier.endpage104en_US
dc.identifier.issn2468-2160
dc.identifier.issn2468-0540
dc.identifier.issue1en_US
dc.identifier.pmid38075202en_US
dc.identifier.scopus2-s2.0-85177864794en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage84en_US
dc.identifier.urihttps://doi.org10.1016/j.ncrna.2023.11.005
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5320
dc.identifier.volume9en_US
dc.identifier.wosWOS:001124613600001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKeai Publishing Ltden_US
dc.relation.ispartofNon-Coding Rna Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectM6aen_US
dc.subjectCanceren_US
dc.subjectMirnaen_US
dc.subjectLncrnaen_US
dc.subjectCircrnaen_US
dc.subjectImmune Responseen_US
dc.titleNon-coding RNA-Mediated N6-Methyladenosine (m6A) deposition: A pivotal regulator of cancer, impacting key signaling pathways in carcinogenesis and therapy responseen_US
dc.typeReview Articleen_US

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