PCL/gelatin nanofibers embedded with doxorubicin-loaded mesoporous silica nanoparticles/silver nanoparticles as an antibacterial and anti-melanoma cancer

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dc.contributor.authorTavira, Melika
dc.contributor.authorMousavi-Khattat, Mohammad
dc.contributor.authorShakeran, Zahra
dc.contributor.authorZarrabi, Ali
dc.date.accessioned2024-05-19T14:45:47Z
dc.date.available2024-05-19T14:45:47Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractMelanoma cancer wound healing is critical and complex and poses a significant challenge to researchers. Drug resistance, adverse side effects, and inefficient localization of chemotherapeutic drugs limit common treatment strategies in melanoma cancer. Using drug delivery nanostructures with low side effects and high efficiency, besides having antibacterial and antiseptic properties, can effectively repair the damage caused by the disease. To this end, this study aimed to develop a drug delivery nanosystem based on doxorubicin (DOX)-loaded aminefunctionalized mesoporous silica nanoparticles (MSNs), linked with green synthesized silver nanoparticles (AgNPs). Characterization methods including microscopic methods and X-ray diffraction (XRD) confirmed the synthesis and functionalization of the well-dispersed nanoparticles with nanosized and uniform structures. The poly(& epsilon;-caprolactone) (PCL) nanofibers as a strong scaffold were produced by the blow spinning method and DOXloaded nanoparticles were blow spun on PCL nanofibers along with gelatin solution. The resulting nanosystem including nanofibers and nanoparticles (NFs/NPS) showed a fine loading percent with a proper release profile of DOX and AgNPs and low hemolysis activity. Moreover, besides preventing infection by AgNPs, the DOX-loaded NFs/NPs could effectively destroy melanoma cancer cells. The attachment of normal cells to the nanoparticlesloaded nanofibers scaffold revealed the possibility of healing wounds caused by melanoma cancer.en_US
dc.description.sponsorshipIsfahan University of Technology Isfahan, Iran; Turkey-Iran Bilateral Cooperation Program of The Scientific and Technological Research Council of Tuerkiy (TUBITAK) [121N152]en_US
dc.description.sponsorshipThe authors are highly grateful to SETUP laboratory members at Isfahan Science and Technology Town (ISTT) , Isfahan University of Technology Isfahan, Iran, for their laboratory supports. Ali Zarrabi ac- knowledges funding support from the Turkey-Iran Bilateral Cooperation Program of The Scientific and Technological Research Council of Tuerkiye (TUBITAK, Project No: 121N152) .en_US
dc.identifier.doi10.1016/j.ijpharm.2023.123162
dc.identifier.issn0378-5173
dc.identifier.issn1873-3476
dc.identifier.pmid37343778en_US
dc.identifier.scopus2-s2.0-85163542477en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org10.1016/j.ijpharm.2023.123162
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5344
dc.identifier.volume642en_US
dc.identifier.wosWOS:001037759200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInternational Journal of Pharmaceuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectMelanoma Canceren_US
dc.subjectPclen_US
dc.subjectGelatin Nanofibersen_US
dc.subjectMesoporous Silica Nanoparticlesen_US
dc.subjectSilver Nanoparticlesen_US
dc.subjectWound Healingen_US
dc.subjectBlow Spinningen_US
dc.titlePCL/gelatin nanofibers embedded with doxorubicin-loaded mesoporous silica nanoparticles/silver nanoparticles as an antibacterial and anti-melanoma canceren_US
dc.typeArticleen_US

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