Curcumin and its derivatives in cancer therapy: potentiating antitumor activity of cisplatin and reducing side effects

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorAbadi, Asal Jalal
dc.contributor.authorMirzaei, Sepideh
dc.contributor.authorMahabady, Mahmood Khaksary
dc.contributor.authorHashemi, Farid
dc.contributor.authorZabolian, Amirhossein
dc.contributor.authorHashemi, Fardin
dc.contributor.authorRaee, Pourya
dc.contributor.authorZarrabi, Ali
dc.date.accessioned2021-11-08T11:11:40Z
dc.date.available2021-11-08T11:11:40Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractCurcumin is a phytochemical isolated from Curcuma longa with potent tumor-suppressor activity, which has shown significant efficacy in pre-clinical and clinical studies. Curcumin stimulates cell death, triggers cycle arrest, and suppresses oncogenic pathways, thereby suppressing cancer progression. Cisplatin (CP) stimulates DNA damage and apoptosis in cancer chemotherapy. However, CP has adverse effects on several organs of the body, and drug resistance is frequently observed. The purpose of the present review is to show the function of curcumin in decreasing CP's adverse impacts and improving its antitumor activity. Curcumin administration reduces ROS levels to prevent apoptosis in normal cells. Furthermore, curcumin can inhibit inflammation via down-regulation of NF-kappa B to maintain the normal function of organs. Curcumin and its nanoformulations can reduce the hepatoxicity, neurotoxicity, renal toxicity, ototoxicity, and cardiotoxicity caused by CP. Notably, curcumin potentiates CP cytotoxicity via mediating cell death and cycle arrest. Besides, curcumin suppresses the STAT3 and NF-kappa B as tumor-promoting pathways, to enhance CP sensitivity and prevent drug resistance. The targeted delivery of curcumin and CP to tumor cells can be mediated nanostructures. In addition, curcumin derivatives are also able to reduce CP-mediated side effects, and increase CP cytotoxicity against various cancer types.en_US
dc.identifier.citationAbadi, A. J., Mirzaei, S., Mahabady, M. K., Hashemi, F., Zabolian, A., Hashemi, F., ... & Sethi, G. (2021). Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects. Phytotherapy Research.en_US
dc.identifier.doi10.1002/ptr.7305en_US
dc.identifier.pmid34697839en_US
dc.identifier.scopus2-s2.0-85117814959en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1002/ptr.7305
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2211
dc.identifier.wosWOS:000710749600001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofPHYTOTHERAPY RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectChemoresistanceen_US
dc.subjectCisplatinen_US
dc.subjectCombination Cancer Chemotherapyen_US
dc.subjectCurcuminen_US
dc.subjectSide Effectsen_US
dc.titleCurcumin and its derivatives in cancer therapy: potentiating antitumor activity of cisplatin and reducing side effectsen_US
dc.typeReview Articleen_US

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