Calvarial bone defects in ovariectomised rats treated with mesenchymal stem cells and demineralised freeze-dried bone allografts

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dc.authoridErdal Karaöz / 0000-0002-9992-833Xen_US
dc.authorscopusidErdal Karaöz / 7003448087
dc.authorwosidErdal Karaöz / IXE-6677-2023
dc.contributor.authorKadiroğlu, Ela Tüleş
dc.contributor.authorAkbalık, Mehmet Erdem
dc.contributor.authorKaraöz, Erdal
dc.contributor.authorKanay, Berna Ersöz
dc.contributor.authorDağ, Ahmet
dc.contributor.authorKetani, Muzaffer Aydın
dc.contributor.authorEroğlu, E. G.
dc.contributor.authorUysal, Ersin
dc.contributor.authorTuncer, Cudi M.
dc.date.accessioned2020-12-14T09:47:39Z
dc.date.available2020-12-14T09:47:39Z
dc.date.issued2020en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractBACKGROUND: The aim of the study was to investigate the ability of a combination of bone marrow mesenchymal stem cells (BM-MSCs) with and without demineralised freeze-dried bone allografts (DFDBAs) to induce bone regeneration in calvarial defects in ovariectomised rats. MATERIALS AND METHODS: Critical size defects were filled with a combination of DFDBAs and BM-MSCs or BM-MSCs alone. Eight weeks after calvarial surgery, the rats were sacrificed. The samples were analysed histologically and immunohistochemically. RESULTS: No difference was observed in vascularisation between groups C1 (animals with cranial defect only, control group) and O1 (animals with cranial defect only, ovariectomy group). Intramembranous ossification was observed at a limited level in groups C2 (animals with cranial defect with MSCs, control group) and O2 (animals with cranial defect with MSCs, ovariectomy group) compared to C1 and O1. In group C3 (animals with DFDBAs with MSCs, control group), the fibrous structures of the matrix became compact as a result of a bone graft having been placed in the cavity, but in group O3 (animals with DFDBAs with MSCs, ovariectomy group), the fibrous tissue was poorly distributed between the bone grafts for the most parts. CONCLUSIONS: We conclude that the insertion of BM-MSCs enhances bone healing; however, the DFDBA/BM-MSC combination has little effect on overcoming impaired bone formation in ovariectomised rats.en_US
dc.identifier.citationKadiroğlu, E. T., Akbalık, M. E., Karaöz, E., Kanay, B. E., Dağ, A., Ketani, M. A., ... & Tuncer, M. C. (2020). Calvarial bone defects in ovariectomized rats treated with mesenchymal stem cells and demineralized freeze-dried bone allografts. Folia Morphologica.en_US
dc.identifier.doi10.5603/FM.a2020.0001en_US
dc.identifier.endpage735en_US
dc.identifier.issn1644-3284en_US
dc.identifier.issue4en_US
dc.identifier.pmid31930468en_US
dc.identifier.scopus2-s2.0-85097210743en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage720en_US
dc.identifier.urihttps://www.doi.org/10.5603/FM.a2020.0001
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1271
dc.identifier.volume79en_US
dc.identifier.wosWOS:000595928900006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKaraöz, Erdal
dc.language.isoenen_US
dc.publisherNLM (Medline)en_US
dc.relation.ispartofFolia morphologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBone Healingen_US
dc.subjectBone Marrow Mesenchymal Stem Cells (BM-MSCs)en_US
dc.subjectCalvarial Defecten_US
dc.subjectDemineralised Freeze-Dried Bone Allografts (DFDBAs)en_US
dc.subjectOvariectomyen_US
dc.titleCalvarial bone defects in ovariectomised rats treated with mesenchymal stem cells and demineralised freeze-dried bone allograftsen_US
dc.typeArticleen_US

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