Development of near-infrared region luminescent N-acetyl-L-cysteine-coated Ag2S quantum dots with differential therapeutic effect

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dc.authoridEngin Ulukaya / 0000-0003-4875-5472en_US
dc.authoridMerve Erkısa Genel / 0000-0002-3127-742X
dc.authorscopusidEngin Ulukaya / 6602927353
dc.authorscopusidMerve Erkısa Genel / 57126208900
dc.authorwosidEngin Ulukaya / K-5792-2018
dc.authorwosidMerve Erkısa Genel / AAM-1001-2020
dc.contributor.authorBuz, Pelin Turhan
dc.contributor.authorDuman, Fatma Demir
dc.contributor.authorErkısa Genel, Merve
dc.contributor.authorDemirci, Gözde
dc.contributor.authorArı, Ferda
dc.contributor.authorUlukaya, Engin
dc.contributor.authorAcar, Havva Yağcı
dc.date.accessioned2020-08-30T20:06:51Z
dc.date.available2020-08-30T20:06:51Z
dc.date.issued2019
dc.departmentİstinye Üniversitesi, Rektörlüken_US
dc.description.abstractAim: N-acetyl-L-cysteine (NAC) is a free radical scavenger. We developed NAC-coated Ag2S (NAC-Ag2S) quantum dot (QD) as an optical imaging and therapeutic agent. Materials & methods: QDs were synthesized in water. Their optical imaging potential and toxicity were studied in vitro. Results: NAC-Ag2S QDs have strong emission, that is tunable between 748 and 840 nm, and are stable in biologically relevant media. QDs showed significant differences both in cell internalization and toxicity in vitro. QDs were quite toxic to breast and cervical cancer cells but not to lung derived cells despite the higher uptake. NAC-Ag2S reduces reactive oxygen species (ROS) but causes cell death via DNA damage and apoptosis. Conclusion: NAC-Ag2S QDs are stable and strong signal-generating theranostic agents offering selective therapeutic effects.en_US
dc.description.sponsorshipScientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113Z164]; Uludag UniversityUludag University [BUAP(F)-2014/3]en_US
dc.description.sponsorshipThis work was supported by Project 113Z164 of Scientific and Technological Research Council of Turkey and Project BUAP(F)-2014/3 of Uludag University. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.en_US
dc.identifier.citationBuz, P. T., Duman, F. D., Erkisa, M., Demirci, G., Ari, F., Ulukaya, E., & Acar, H. Y. (2019). Development of near-infrared region luminescent N-acetyl-L-cysteine-coated Ag2S quantum dots with differential therapeutic effect. Nanomedicine, 14(8), 969-987.en_US
dc.identifier.doi10.2217/nnm-2018-0214en_US
dc.identifier.endpage988en_US
dc.identifier.issn1743-5889en_US
dc.identifier.issn1748-6963en_US
dc.identifier.issue8en_US
dc.identifier.pmid30917096en_US
dc.identifier.scopus2-s2.0-85064554881en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage969en_US
dc.identifier.urihttps://doi.org/10.2217/nnm-2018-0214
dc.identifier.urihttps://hdl.handle.net/20.500.12713/637
dc.identifier.volume14en_US
dc.identifier.wosWOS:000472680000004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorErkısa Genel, Merveen_US
dc.institutionauthorUlukaya, Enginen_US
dc.language.isoenen_US
dc.publisherFuture Medicine Ltden_US
dc.relation.ispartofNanomedicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAg2s Quantum Dotsen_US
dc.subjectApoptosisen_US
dc.subjectDna Damageen_US
dc.subjectImagingen_US
dc.subjectN-Acetyl-L-Cysteine (Nac)en_US
dc.subjectReactive Oxygen Species (Ros)en_US
dc.titleDevelopment of near-infrared region luminescent N-acetyl-L-cysteine-coated Ag2S quantum dots with differential therapeutic effecten_US
dc.typeArticleen_US

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