GAS5 oligonucleotides as therapeutic agents in breast cancer
Yükleniyor...
Dosyalar
Tarih
2016
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Ame Publ Co
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Although relatively less is known about the long non-coding RNA (lncRNA) than the essential protein coding genes, several of them have organismal functions such as lethal knockouts, apoptosis etc. (1,2). Growth arrest specific genes 5 (GAS5) has proven to be pro-apoptotic in breast cancer (BC) cell lines (3). In their paper entitled “The hormone response element mimic sequence of GAS5 lncRNA is sufficient to induce apoptosis in breast cancer cells” published in March issue of Oncotarget by Pickard and Williams (4) report that an oligonucleotide representing the hormone response element mimic (HREM) sequence within GAS5 alone is able to promote the apoptosis of BC cells similar to fulllength GAS5.
Açıklama
Anahtar Kelimeler
Kaynak
Translational Cancer Research
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
5
Sayı
Künye
Fayda, M., & Gezer, U. (2016). GAS5 oligonucleotides as therapeutic agents in breast cancer. Translational Cancer Research, 5, S567–S568. https://doi.org/10.21037/tcr.2016.08.42
