Nesfatin-1 ameliorates oxidative brain damage and memory impairment in rats induced with a single acute epileptic seizure

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dc.authoridAyça Karagöz Köroğlu / 0000-0002-2532-8091en_US
dc.authorscopusidAyça Karagöz Köroğlu / 57217538082en_US
dc.authorwosidAyça Karagöz Köroğlu / DXI-1614-2022
dc.contributor.authorArabacı Tamer, Sevil
dc.contributor.authorKoyuncuoğlu, Türkan
dc.contributor.authorKaragöz Köroğlu, Ayça
dc.contributor.authorAkakın, Dilek
dc.contributor.authorYüksel, Meral
dc.contributor.authorYeğen, Berrak Ç.
dc.date.accessioned2022-03-03T12:49:30Z
dc.date.available2022-03-03T12:49:30Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractAims: We aimed to investigate putative neuroprotective effects of nesfatin-1 on oxidative brain injury and memory dysfunction induced by a single epileptic seizure and to compare these effects with those of antiepileptic phenytoin. Main methods: Wistar albino rats were randomly divided into a control group and pentylenetetrazole (PTZ)-seizure groups pretreated intraperitoneally (ip) with saline or nesfatin-1 (NES-1; 0.3, 1 or 3 ?g/kg/day) or phenytoin (PHE; 40 mg/kg/day) or PHE + NES-1 (0.3 ?g/kg/day) at 30 min before the single-dose PTZ injection (45 mg/kg; ip). All treatments were repeated at the 24th and 48th h of the provoked epileptic seizure. Passive-avoidance test was performed to assess memory function. The rats were decapitated at the 72nd hour of seizures and brain tissues were analyzed for histopathological changes and for measuring levels of malondialdehyde, glutathione, myeloperoxidase activity and reactive oxygen/nitrogen species. Key findings: In parallel to the effects of phenytoin, NES-1 reduced seizure score, elevated antioxidant glutathione content, depressed generation of nitric oxide and protected against seizure-induced neuronal damage. Additionally, increased malondialdehyde levels and elevated glial fibrillary acidic protein immunoreactivity in the cortex and hippocampus were decreased and memory dysfunction was improved by NES-1. However, NES-1 had no impact on myeloperoxidase activity or production of reactive oxygen species in the brain. Significance: The findings of the present study demonstrate that nesfatin-1 treatment provides neuroprotection against seizure-induced oxidative damage and memory dysfunction by inhibiting reactive nitrogen species and upregulating antioxidant capacity, indicating its potential in alleviating memory deficits and increasing the effectiveness of conventional anti-convulsant therapies. © 2022en_US
dc.identifier.citationArabacı Tamer, S., Koyuncuoğlu, T., Karagöz Köroğlu, A., Akakın, D., Yüksel, M., & Yeğen, B. Ç. (2022). Nesfatin-1 ameliorates oxidative brain damage and memory impairment in rats induced with a single acute epileptic seizure. Life Sciences, 294 doi:10.1016/j.lfs.2022.120376en_US
dc.identifier.doi10.1016/j.lfs.2022.120376en_US
dc.identifier.issn0024-3205en_US
dc.identifier.pmid35123998en_US
dc.identifier.scopus2-s2.0-85124233306en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.lfs.2022.120376
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2523
dc.identifier.volume294en_US
dc.identifier.wosWOS:000805305600002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKaragöz Köroğlu, Ayça
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofLife Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectMemory Dysfunctionen_US
dc.subjectNesfatin-1en_US
dc.subjectOxidative Injuryen_US
dc.subjectSeizureen_US
dc.titleNesfatin-1 ameliorates oxidative brain damage and memory impairment in rats induced with a single acute epileptic seizureen_US
dc.typeArticleen_US

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