The clinical characteristics of sarcoid arthropathy based on a prospective cohort study

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dc.authoridŞenol Kobak / 0000-0001-8270-640Xen_US
dc.authorscopusidŞenol Kobak / 12782228700
dc.authorwosidŞenol Kobak / AAO-2482-2020
dc.contributor.authorKobak, Şenol
dc.contributor.authorSever, Fidan
dc.contributor.authorUsluer, Ozan
dc.contributor.authorGöksel, Tuncay
dc.contributor.authorOrman, Mehmet
dc.date.accessioned2020-08-30T20:08:22Z
dc.date.available2020-08-30T20:08:22Z
dc.date.issued2016
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Sarcoidosis is known as a Th1-mediated disease, which can mimic many primary rheumatologic diseases or sometimes co-exist with them. Clinical characteristics of sarcoid arthropathy are not well described and the studies reported in the literature so far are mostly based on data from referrals. The aim of this study was to evaluate the incidence and clinical characteristics of sarcoid arthropathy. Methods: All our patients were prospectively evaluated in our rheumatology outpatient center from 2011 to 2015. A total of 114 (32 male) patients with sarcoidosis who were admitted to our clinic were included in the study. Clinical, demographical, laboratory, radiological and histological data of these patients obtained during 4-year follow-up and treatment period were compiled and analyzed. Results: The mean patient age was 48.1 years (range, 20-82 years), and the mean disease duration was 40.5 months (range, 1-300 months). Sarcoid arthritis was observed in 71 (62.3%), and arthralgia in 106 (92.9%) patients. Out of the 71 patients with arthritis, 61 (85.9%) had involvement of ankle, 7 (9.8%) knee, 2 (2.8%) wrist, MCP and PIP joints, and 1 (1.4%) had shoulder periarthritis. Oligoarthritis (two to four joints) was the most common pattern followed by monoarthritis and polyarthritis. Arthritis and erytjhema nodosum and arthritis and female sex was found to be correlated (p = 0.03 and p = 0.001). Again, in patients with arthritis, even higher levels of CRP/ESR as well as ANA and RF positivity were observed (p = 0.03, p = 0.01, p = 0.01, and p = 0.02, respectively). A total of 11 patients had another rheumatic pathology concurrent with sarcoidosis. Conclusions: Inflammatory arthritis occurs in a majority of patients with sarcoidosis. Acute arthritis with bilateral ankle involvement is the most common pattern of sarcoid arthropathy. Sarcoidosis can mimic many primary rheumatic diseases or may coexist with them. Sarcoidosis should be considered not only as a mimicker but also as a Th1-mediated primary rheumatologic pathology.en_US
dc.identifier.citationKobak, S., Sever, F., Usluer, O., Goksel, T., & Orman, M. (2016). The clinical characteristics of sarcoid arthropathy based on a prospective cohort study. Therapeutic Advances in Musculoskeletal Disease, 8(6), 220-224.en_US
dc.identifier.doi10.1177/1759720X16670598en_US
dc.identifier.endpage224en_US
dc.identifier.issn1759-720Xen_US
dc.identifier.issn1759-7218en_US
dc.identifier.issue6en_US
dc.identifier.pmid28255335en_US
dc.identifier.scopus2-s2.0-84996490493en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage220en_US
dc.identifier.urihttps://doi.org/10.1177/1759720X16670598
dc.identifier.urihttps://hdl.handle.net/20.500.12713/927
dc.identifier.volume8en_US
dc.identifier.wosWOS:000388861800002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKobak, Şenolen_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofTherapeutic Advances In Musculoskeletal Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectArthropathyen_US
dc.subjectIncidenceen_US
dc.subjectSarcoidosisen_US
dc.titleThe clinical characteristics of sarcoid arthropathy based on a prospective cohort studyen_US
dc.typeArticleen_US

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