Skin disorders in women with poor obstetric history: MTHFR polymorphisms and importance of preconceptional counseling

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dc.authoridDONMEZ, HANIFE GULER/0000-0002-7413-4939
dc.authoridBeksac, M.Sinan/0000-0001-6362-787X
dc.authoridCagan, Murat/0000-0003-0629-4401
dc.authorwosidDONMEZ, HANIFE GULER/G-9145-2013
dc.contributor.authorCagan, Murat
dc.contributor.authorDonmez, Hanife Guler
dc.contributor.authorFadiloglu, Erdem
dc.contributor.authorBeksac, Mehmet Sinan
dc.date.accessioned2024-05-19T14:45:48Z
dc.date.available2024-05-19T14:45:48Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractObjectives: This study focused on the link between skin disorders and Methylenetetrahydrofolate reductase (MTHFR) polymorphisms. Methods: Study cases were taken from a pre-conceptional care program where patients with poor obstetric history were evaluated in terms of systemic disorders including skin diseases. This retrospective cohort (n = 472) consisted of 110 (23.3%) and 362 (76.7%) women with or without skin disorders, respectively. For ease of analysis, the history of skin diseases was classified into seven categories: (1) acne/rosacea/other acneiform disorders; (2) fungal disease; (3) pruritis/xerosis; (4) psoriasis vulgaris; (5) acrochordons and other benign skin growths; (6) urticaria/dermatitis; and (7) viral diseases. Results: In this retrospective cohort of 472 women, we explored the impact of MTHFR A1298C and C677T polymorphisms on skin disorders. Despite similar allelic frequencies, our findings revealed a statistically significant association between the presence of MTHFR polymorphisms and skin disorders (p = .027). Subgroup analysis indicated significantly higher rates of MTHFR polymorphisms in patients with psoriasis vulgaris (p = .033) and acrochordons (p = .030), highlighting their potential relevance in specific skin disorder subtypes. Conclusions: The increased prevalence of psoriasis and acrochordons among women with MTHFR deficiency underscores the complex relationship between genetic factors and dermatological health. Our findings emphasized the critical role of MTHFR polymorphisms not only in poor obstetric history but also as significant contributors to skin disorders. This dual association highlights the importance of comprehensive preconception counseling, especially customized for women affected by skin disorders.en_US
dc.identifier.doi10.1080/03007995.2024.2337668
dc.identifier.issn0300-7995
dc.identifier.issn1473-4877
dc.identifier.pmid38557333en_US
dc.identifier.scopus2-s2.0-85190290524en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org10.1080/03007995.2024.2337668
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5353
dc.identifier.wosWOS:001198489200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofCurrent Medical Research and Opinionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectMethylenetetrahydrofolate Reductase Polymorphismsen_US
dc.subjectDna Methylationen_US
dc.subjectSkin Disordersen_US
dc.subjectPsoriasis Vulgarisen_US
dc.subjectAcrochordonsen_US
dc.titleSkin disorders in women with poor obstetric history: MTHFR polymorphisms and importance of preconceptional counselingen_US
dc.typeArticleen_US

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