Catheter-Directed Ionic Liquid Embolic Agent for Rapid Portal Vein Embolization, Segmentectomy, and Bile Duct Ablation

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dc.contributor.authorCevik, Enes
dc.contributor.authorAlbadawi, Hassan
dc.contributor.authorZhang, Zefu
dc.contributor.authorDemirlenk, Yusuf
dc.contributor.authorAtar, Dila
dc.contributor.authorKeum, Chris
dc.contributor.authorKim, Jinjoo
dc.date.accessioned2024-05-19T14:38:45Z
dc.date.available2024-05-19T14:38:45Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractEmbolic materials currently in use for portal vein embolization (PVE) do not treat the tumor, which poses a risk for tumor progression during the interval between PVE and surgical resection. Here, is developed an ionic-liquid-based embolic material (LEAD) for portal vein embolization, liver ablation, and drug delivery. LEAD is optimized and characterized for diffusivity, X-ray visibility, and cytotoxicity. In the porcine renal embolization model, LEAD delivered from the main renal artery reached vasculature down to 10 microns with uniform tissue ablation and delivery of small and large therapeutics. In non-survival and survival porcine experiments, successful PVE is achieved in minutes, leading to the expected chemical segmentectomy, and delivery of a large protein drug (i.e., Nivolumab) with LEAD. In cholangiocarcinoma mouse tumor models and in ex vivo human tumors, LEAD consistently achieved an effective ablation and wide drug distribution. Furthermore, various strains of drug-resistant patient-derived bacteria showed significant susceptibility to LEAD, suggesting that LEAD may also prevent infectious complications resulting from tissue ablation. With its capabilities to embolize, ablate, and deliver therapeutics, ease of use, and a high safety profile demonstrated in animal studies, LEAD offers a potential alternative to tumor ablation with or without PVE for FLR growth. Embolic materials currently used for PVE do not treat the tumor, risking tumor progression during the interval between PVE and surgery. Here, an ionic-liquid-based embolic material (LEAD) is developed that can embolize, ablate, and deliver therapeutics. With its ease of use and a high safety profile demonstrated in animal studies, LEAD offers a potential alternative to tumor ablation with or without PVE for FLR growth. imageen_US
dc.description.sponsorshipMayo Clinic [R01CA257558, R01HL140951, R01DK130566, R01HL165176, R01HL137193]; National Institutes of Health; Clinician Investigator Award from the Mayo Clinic; Christian Haub Family Career Development Awarden_US
dc.description.sponsorshipR.O. gratefully acknowledges funding from the National Institutes of Health (R01CA257558, R01HL140951, R01DK130566, R01HL165176, and R01HL137193) and the Clinician Investigator Award from the Mayo Clinic. H.A. acknowledges funding from the Christian Haub Family Career Development Award. The authors gratefully acknowledge Dr. Gregory Gores and Dr. Nathan Werneburg for providing the SB1 cholangiocarcinoma cell line.en_US
dc.identifier.doi10.1002/adma.202402570
dc.identifier.issn0935-9648
dc.identifier.issn1521-4095
dc.identifier.pmid38678378en_US
dc.identifier.scopus2-s2.0-85192158467en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org10.1002/adma.202402570
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4596
dc.identifier.wosWOS:001214920900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofAdvanced Materialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAblationen_US
dc.subjectDrug Deliveryen_US
dc.subjectEmbolizationen_US
dc.subjectImmunotherapyen_US
dc.subjectPortal Veinen_US
dc.titleCatheter-Directed Ionic Liquid Embolic Agent for Rapid Portal Vein Embolization, Segmentectomy, and Bile Duct Ablationen_US
dc.typeArticleen_US

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