Differences between adult and pediatric chronic spontaneous urticaria from a cohort of 751 patients: Clinical features, associated conditions and indicators of treatment response

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dc.authoridTerzi, Özlem/0000-0002-9524-5582
dc.authoridCan, Pelin/0000-0002-9124-5817
dc.authoridKocaturk, Emek/0000-0003-2801-0959
dc.authoridOrnek, Sinem Ayse/0000-0002-1536-6035
dc.authoridozceker, deniz/0000-0002-0032-6727
dc.authorwosidTerzi, Özlem/D-7697-2016
dc.authorwosidCan, Pelin/JTD-2412-2023
dc.authorwosidKocaturk, Emek/ABD-8447-2020
dc.authorwosidSarac, Esra/AAV-8776-2021
dc.authorwosidOrnek, Sinem Ayse/ABF-1555-2021
dc.contributor.authorOzceker, Deniz
dc.contributor.authorCan, Pelin Kuteyla
dc.contributor.authorTerzi, Ozlem
dc.contributor.authorOrnek, Sinem Ayse
dc.contributor.authorDegirmentepe, Ece Nur
dc.contributor.authorKiziltac, Kubra
dc.contributor.authorSarac, Esra
dc.date.accessioned2024-05-19T14:38:52Z
dc.date.available2024-05-19T14:38:52Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBackgroundChronic spontaneous urticaria (CSU) is a common disease both in the pediatric and in the adult population. However, there are differences between the two patient populations with respect to etiological factors, comorbidities, and treatment responses. Our aim was to determine differences between pediatric and adult CSU in terms of clinical characteristics, laboratory parameters, comorbidities, response to treatment, and indicators of response. MethodsA retrospective analysis of CSU patients was performed. Data regarding differences between pediatric and adult CSU patients were analyzed. Indicators of treatment response were determined separately in both pediatric and adult patients. ResultsOf 751 CSU patients (162 pediatrics and 589 adults), female dominancy (48.8% vs. 69.6%) and rate of angioedema (19.1% vs. 59.8%) were lower, and disease duration (5 months vs. 12 months) was shorter in pediatric patients. Anti-TPO positivity (24.7% vs. 9%), elevated CRP (46.5% vs. 11.1%), eosinopenia (38.5% vs. 18.1%), and skin prick test positivity (39.3% vs. 28.8%) were significantly more frequent in adult patients. Response to antihistamines was higher in the pediatric group, and only 7% used omalizumab versus 20.8% in the adults. The comparisons were also performed between <12-year and >= 12-year patients and yielded similar results. ConclusionPediatric CSU shows distinct characteristics such as lower incidence of angioedema and antithyroid antibodies, and it responds better to antihistamines. These suggest that CSU becomes more severe and refractory in adolescents and adults. Adolescent CSU shows features similar to adult CSU rather than pediatric CSU.en_US
dc.identifier.doi10.1111/pai.13925
dc.identifier.issn0905-6157
dc.identifier.issn1399-3038
dc.identifier.issue2en_US
dc.identifier.pmid36825740en_US
dc.identifier.scopus2-s2.0-85148618254en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org10.1111/pai.13925
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4635
dc.identifier.volume34en_US
dc.identifier.wosWOS:000935411200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatric Allergy and Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAdolescenten_US
dc.subjectAdulten_US
dc.subjectAngioedemaen_US
dc.subjectAntihistamineen_US
dc.subjectChildrenen_US
dc.subjectChronic Spontaneous Urticariaen_US
dc.subjectOmalizumaben_US
dc.subjectPediatricen_US
dc.subjectTreatmenten_US
dc.titleDifferences between adult and pediatric chronic spontaneous urticaria from a cohort of 751 patients: Clinical features, associated conditions and indicators of treatment responseen_US
dc.typeArticleen_US

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