Uncovering the promising role of grape pomace as a modulator of the gut microbiome: An in-depth review*

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dc.authoridbarile, daniela/0000-0002-3889-1596
dc.contributor.authorSinrod, Amanda J. G.
dc.contributor.authorShah, Ishita M.
dc.contributor.authorSurek, Ece
dc.contributor.authorBarile, Daniela
dc.date.accessioned2024-05-19T14:41:57Z
dc.date.available2024-05-19T14:41:57Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractGrape pomace is the primary wine coproduct consisting primarily of grape seeds and skins. Grape pomace holds immense potential as a functional ingredient to improve human health while its valorization can be beneficial for industrial sustainability. Pomace contains bioactive compounds, including phenols and oligosaccharides, most of which reach the colon intact, enabling interaction with the gut microbiome. Microbial analysis found that grape pomace selectively promotes the growth of many commensal bacteria strains, while other types of bacteria, including various pathogens, are highly sensitive to the pomace and its components and are inactivated. In vitro studies showed that grape pomace and its extracts inhibit the growth of pathogenic bacteria in Enterobacteriaceae family while increasing the growth and survival of some beneficial bacteria, including Bifidobacterium spp. and Lactobacillus spp. Grape pomace supplementation in mice and rats improves their gut microbiome complexity and decreases diet-induced obesity as well as related illnesses, including insulin resistance, indicating grape pomace could improve human health. A human clinical trial found that pomace, regardless of its phenolic content, had cardioprotective effects, suggesting that dietary fiber induced those health benefits. To shed light on the active components, this review explores the potential prebiotic capacity of select bioactive compounds in grape pomace.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)en_US
dc.description.sponsorshipAmanda J.G. Sinrod was partially supported by a grant from Sonomaceuticals, LLC (Santa Rosa, CA). Ece Surek was financially supported by The Scientific and Technological Research Council of Turkey (TUBITAK) international postdoctoral research fellowship program for her postdoctoral studies in U.S.r supported by The Scientific and Technological Research Council of Turkey (TUBITAK) international postdoctoral research fellowship program for her postdoctoral studies in U.S. No additional information is available for this paper.en_US
dc.identifier.doi10.1016/j.heliyon.2023.e20499
dc.identifier.issn2405-8440
dc.identifier.issue10en_US
dc.identifier.pmid37867799en_US
dc.identifier.scopus2-s2.0-85174934791en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org10.1016/j.heliyon.2023.e20499
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5181
dc.identifier.volume9en_US
dc.identifier.wosWOS:001112886900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCell Pressen_US
dc.relation.ispartofHeliyonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectGrape Pomaceen_US
dc.subjectGut Microbiomeen_US
dc.subjectOligosaccharideen_US
dc.subjectPhenolic Compoundsen_US
dc.subjectPrebioticen_US
dc.titleUncovering the promising role of grape pomace as a modulator of the gut microbiome: An in-depth review*en_US
dc.typeReview Articleen_US

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