Evaluation of neurotoxicity of multiple anesthesia in children using visual evoked potentials

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dc.authoridSacit Karamürsel / 0000-0002-7534-9392
dc.authorscopusidSacit Karamürsel / 7004361830
dc.authorwosidSacit Karamürsel / O-9371-2019
dc.contributor.authorOba, Sibel
dc.contributor.authorIşıl, Canan Tüley
dc.contributor.authorTürk, Hacer Şebnem
dc.contributor.authorKaramürsel, Sacit
dc.contributor.authorAksu, Serkan
dc.contributor.authorKaba, Meltem
dc.contributor.authorDokucu, Ali İhsan
dc.date.accessioned2020-08-30T20:07:04Z
dc.date.available2020-08-30T20:07:04Z
dc.date.issued2019
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives: Anesthetic applications may cause increased neuronal damage in infants and children. Commonly cognitive or learning disability tests were used to investigate the neurological progress in children. Visual Evoked Potential is a gross electrical signal generated by the occipital regions of the cerebral cortex in response to visual stimulation and an objective assessment of brain function. In this study, to acquire more objective results, Visual Evoked Potential responses of children who had multiple exposures to anesthesia during the treatment of corrosive esophagitis were compared to children who have never received anesthesia before. Methods: In this prospective, single-blinded, randomized, controlled study, 25 children, who were admitted to our pediatric surgery clinic because of corrosive esophagitis and who received general anesthesia more than 15 times composed Group-P; 25 children, who admitted to our well-child-clinic and who had never received anesthesia before consisted Group-C. The flash and pattern VEP responses of both groups were measured at the electrophysiology laboratory without any anesthetic drug application. The VEP responses of children in Group-P were recorded at least three days after the last exposure to anesthesia. Results: Latencies and amplitudes of the N2 and P2 components of the pattern and flash VEP responses were statistically significantly different between the two groups (p=0.000). Conclusion: This study shows that in children who had repeated anesthetic applications VEP parameters are significantly altered. We believe that VEP responses may be a reliable objective criterion for the evaluation of anesthesia neurotoxicity.en_US
dc.identifier.citationOba, S., Işıl, C. T., Türk, H. Ş., Karamürsel, S., Aksu, S., Kaba, M., ... & Dokucu, A. I. (2019). Evaluation of Neurotoxicity of Multiple Anesthesia in Children Using Visual Evoked Potentials. Şişli Etfal Hastanesi tıp Bülteni, 53(3), 284.en_US
dc.identifier.doi10.14744/SEMB.2018.59454en_US
dc.identifier.endpage289en_US
dc.identifier.issn1302-7123en_US
dc.identifier.issn1308-5123en_US
dc.identifier.issue3en_US
dc.identifier.pmid32377097en_US
dc.identifier.startpage284en_US
dc.identifier.trdizinid347236en_US
dc.identifier.urihttps://doi.org/10.14744/SEMB.2018.59454
dc.identifier.urihttps://hdl.handle.net/20.500.12713/687
dc.identifier.volume53en_US
dc.identifier.wosWOS:000483989700013en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKaramürsel, Saciten_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofMedical Bulletin of Sisli Etfal Hospitalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnesthesiaen_US
dc.subjectCorrosive Esophagitisen_US
dc.subjectNeurotoxicityen_US
dc.subjectPediatricen_US
dc.subjectVisual Evoked Potentialen_US
dc.titleEvaluation of neurotoxicity of multiple anesthesia in children using visual evoked potentialsen_US
dc.typeArticleen_US

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