A palladium(II)-saccharinate complex of terpyridine exerts higher anticancer potency and less toxicity than cisplatin in a mouse allograft model

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dc.authoridEngin Ulukaya / 0000-0003-4875-5472en_US
dc.authorscopusidEngin Ulukaya / 6602927353
dc.authorwosidEngin Ulukaya / K-5792-2018
dc.contributor.authorÇetin, Yüksel
dc.contributor.authorAdıgüzel, Zelal
dc.contributor.authorPolat, Hivda U.
dc.contributor.authorAkkoç, Tolga
dc.contributor.authorTaş, Arzu
dc.contributor.authorCevatemre, Buse
dc.contributor.authorÇelik, Gokalp
dc.contributor.authorÇarıkçı, Barış
dc.contributor.authorYılmaz, Veysel T.
dc.contributor.authorUlukaya, Engin
dc.contributor.authorAçılan, Ceyda
dc.date.accessioned2020-08-30T20:08:06Z
dc.date.available2020-08-30T20:08:06Z
dc.date.issued2017
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractThe main aim of this study is to assess the safety and antitumor efficacy of a palladium(II) (Pd)-saccharinate complex with terpyridine. To characterize the Pd(II) complex in vitro, its cytotoxicity was evaluated using a water-soluble tetrazolium salt cell viability assay and the mechanism of cell death was assessed by DNA fragmentation/condensation and live cell imaging analyses. The antitumor efficacy and safety of the Pd(II) complex in-vivo were examined by analyzing reduction in tumor size, changes in body and organ weight, histopathological analysis of liver, kidney, and tumor sections, and biochemical analysis of serum in C57BL/6 mice. Our results showed that the Pd(II) complex was more cytotoxic to cancer cells than noncancer cell lines and caused cell death through apoptotic pathways. The treatment of the Pd(II) complex in tumor-bearing mice effectively reduced the tumor size at half the dose used for cisplatin. The Pd(II) complex appeared to exert less liver damage than the cisplatin-based complex on changes in the hepatic enzymes levels in the serum. Hence, the complex appears to be a potential chemotherapeutic drug with high antitumor efficacy and fewer hepatotoxic complications, providing an avenue for further studies. Anti-Cancer Drugs 28: 898-910 Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.en_US
dc.description.sponsorshipScientific and Technological Research Institute of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)en_US
dc.description.sponsorshipThis work was supported by the internal funding of The Scientific and Technological Research Institute of Turkey (TUBITAK).en_US
dc.identifier.citationCetin, Y., Adiguzel, Z., Polat, H. U., Akkoc, T., Tas, A., Cevatemre, B., … Acilan, C. (2017). A palladium(II)-saccharinate complex of terpyridine exerts higher anticancer potency and less toxicity than cisplatin in a mouse allograft model. Anti-Cancer Drugs, 28(8), 898–910. https://doi.org/10.1097/CAD.0000000000000531en_US
dc.identifier.doi10.1097/CAD.0000000000000531en_US
dc.identifier.endpage910en_US
dc.identifier.issn0959-4973en_US
dc.identifier.issn1473-5741en_US
dc.identifier.issue8en_US
dc.identifier.pmid28657910en_US
dc.identifier.scopus2-s2.0-85021410717en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage898en_US
dc.identifier.urihttps://doi.org/10.1097/CAD.0000000000000531
dc.identifier.urihttps://hdl.handle.net/20.500.12713/883
dc.identifier.volume28en_US
dc.identifier.wosWOS:000408162400009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUlukaya, Enginen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAnti-Cancer Drugsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnticancer Drugsen_US
dc.subjectAntitumor Activityen_US
dc.subjectApoptosisen_US
dc.subjectIn-Vitro Characterizationen_US
dc.subjectIn-Vivo Characterizationen_US
dc.subjectPalladium(Ii)-Saccharinate Complex With Terpyridineen_US
dc.subjectToxicityen_US
dc.titleA palladium(II)-saccharinate complex of terpyridine exerts higher anticancer potency and less toxicity than cisplatin in a mouse allograft modelen_US
dc.typeArticleen_US

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