The ameliorative effect of rosmarinic acid and epigallocatechin gallate against doxorubicin-induced genotoxicity

Basit Öğe Kaydı
dc.authoridHelvacioglu Akyuz, Sinem/0000-0002-3144-5024
dc.authoridBankoglu, Ezgi Eylul/0000-0001-7488-6228
dc.authorwosidHelvacioglu Akyuz, Sinem/GWQ-9714-2022
dc.contributor.authorHelvacioglu, Sinem
dc.contributor.authorCharehsaz, Mohammad
dc.contributor.authorBankoglu, Ezgi Eyluel
dc.contributor.authorStopper, Helga
dc.contributor.authorAydin, Ahmet
dc.date.accessioned2024-05-19T14:40:57Z
dc.date.available2024-05-19T14:40:57Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractDoxorubicin (Dox), an effective anticancer agent, is known for its genotoxic effects on normal cells. Phenolic compounds, renowned for their antitumor, antioxidant, and antigenotoxic properties, have gained prominence in recent years. This study investigates the individual and combined protective effects of rosmarinic acid (RA) and epigallocatechin gallate (EGCG) against Dox-induced genotoxicity using various in vitro test systems. The synergistic/antagonistic interaction of these combinations on Dox's chemotherapeutic effect is explored in breast cancer cell lines. Both RA and EGCG significantly mitigate Dox-induced genotoxicity in comet, micronucleus, and Ames assays. While Dox exhibits higher selectivity against MCF-7 cells, EGCG and RA show greater selectivity against MDA-MB-231 cells. The coefficient of drug interaction reveals a synergistic effect when RA or EGCG is combined with Dox in breast cancer cells. In conclusion, both EGCG and RA effectively reduce Dox-induced genetic damage and enhance Dox's cell viability-reducing effect in breast cancer cells.en_US
dc.description.sponsorshipGerman Academic Exchange Service (DAAD) Fellowship [91696229]en_US
dc.description.sponsorshipNo Statement Availableen_US
dc.identifier.doi10.1080/01480545.2024.2332790
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.pmid38529831en_US
dc.identifier.scopus2-s2.0-85189504808en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org10.1080/01480545.2024.2332790
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5041
dc.identifier.wosWOS:001190998000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectDoxorubicinen_US
dc.subjectRosmarinic Aciden_US
dc.subjectEpigallocatechin Gallateen_US
dc.subjectAmes Testen_US
dc.subjectComet Assayen_US
dc.subjectMicronucleusen_US
dc.titleThe ameliorative effect of rosmarinic acid and epigallocatechin gallate against doxorubicin-induced genotoxicityen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu