The therapeutic effects of coenzyme Q10 on surgically induced endometriosis in Sprague Dawley rats

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dc.authoridAyşe Köylü / 0000-0001-8344-814Xen_US
dc.authorscopusidAyşe Köylü / 57202948246
dc.authorwosidAyşe Köylü / ACR-1233-2022en_US
dc.contributor.authorAkarca Dizakar, Saadet Özen
dc.contributor.authorDemirel, Mürşide Ayşe
dc.contributor.authorCoşkun Akçay, Neslihan
dc.contributor.authorSipahi, Mehmet
dc.contributor.authorKarakoç Sökmensüer, Lale
dc.contributor.authorBoyunağa, Hakan
dc.contributor.authorKöylü, Ayşe
dc.contributor.authorÖmeroğlu, Suna
dc.date.accessioned2022-09-16T08:39:01Z
dc.date.available2022-09-16T08:39:01Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractThe aim of this study was to evaluate the effects of coenzyme Q10 in the treatment of endometriosis rat models. Twenty seven Sprague Dawley rats were divided into four groups; Control Group (n = 7; Endometriosis group), Reference Group (n = 6; Endometriosis + Buserelin acetate, 20 mg/kg), CoQ10 Group-I (n = 7; Endometriosis + CoQ10, 50 mg/kg) and CoQ10 Group-II (n = 7; Endometriosis + CoQ10, 100 mg/kg). At the end of the experiment, all the rats were sacrificed, and the volume and histoarchitecture of endometrial implants were evaluated. The mast cells were determined by Toluidine blue and collagen fiber density was analysed by Masson's Trichrome staining. Tumour necrosis factor and vascular endothelial growth factor (VEGF) levels were analysed by enzyme-linked immunosorbent assay in peritoneal fluid and VEGF and matrix metalloproteinase-9 (MMP-9) were evaluated by immunohistochemistry. Terminal deoxynucleotidil transferase-mediated dUTP Nick end labelling (TUNEL) was also used for the detection of apoptotic cells. The CoQ10 treatment significantly decreased the volume of endometriotic implants, VEGF, and MMP-9 immunoreactivity and increased TUNEL-positive cells. The findings of the study suggest that CoQ10 can be used in endometriosis treatment by suppressing the endometriotic implants.IMPACT STATEMENTWhat is already known on this subject? Endometriosis is a gynaecological disorder and previous studies have shown that different treatments with antioxidants cause significant regression in the endometriotic implants.What the results of this study add? In this study, CoQ10 reduced intra-abdominal adhesion scores and volume of the endometriotic implants. In addition, CoQ10 treatment affected mast cell, TNF-?, VEGF, and MMP-9.What of these findings for clinical practice and/or further research? CoQ10 treatments may be possible to apply, it can contribute to science in terms of a new therapeutic treatment for endometriosis. Further studies are required to evaluate the Coenzyme Q10's effects on pain and subfertility in endometriosis.en_US
dc.identifier.citationAkarca-Dizakar SÖ, Demirel MA, Coşkun Akçay N, Sipahi M, Karakoç Sökmensüer L, Boyunaga H, Köylü A, Ömeroğlu S. The therapeutic effects of coenzyme Q10 on surgically induced endometriosis in Sprague Dawley rats. J Obstet Gynaecol. 2022 Sep 1:1-9. doi: 10.1080/01443615.2022.2114322. Epub ahead of print. PMID: 36048875.en_US
dc.identifier.doi10.1080/01443615.2022.2114322en_US
dc.identifier.issn0144-3615en_US
dc.identifier.issue9en_US
dc.identifier.pmid36048875en_US
dc.identifier.scopus2-s2.0-85137091388en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttp://doi.org/10.1080/01443615.2022.2114322
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3142
dc.identifier.volume1en_US
dc.identifier.wosWOS:000849763500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKöylü, Ayşe
dc.language.isoenen_US
dc.publisherTaylor and Francisen_US
dc.relation.ispartofJournal of Obstetrics and Gynaecology : The Journal of the Institute of Obstetrics and Gynaecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoenzyme Q10en_US
dc.subjectMMP-9en_US
dc.subjectVEGFen_US
dc.subjectEndometriosisen_US
dc.subjectInfertilityen_US
dc.titleThe therapeutic effects of coenzyme Q10 on surgically induced endometriosis in Sprague Dawley ratsen_US
dc.typeArticleen_US

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