Characteristics of Turkish children with Type 2 diabetes at onset: a multicentre, cross-sectional study

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dc.authoridTeoman Akçay / 0000-0002-8252-7089
dc.authorscopusidTeoman Akçay / 23968688000
dc.authorwosidTeoman Akçay / AFG-8460-2022
dc.contributor.authorHatun, S.
dc.contributor.authorMutlu, G. Yeşiltepe
dc.contributor.authorCinaz, P.
dc.contributor.authorTuran, S.
dc.contributor.authorEkberzade, A.
dc.contributor.authorBereket, A.
dc.contributor.authorErbaş, M. Y.
dc.contributor.authorÖnal, H.
dc.contributor.authorBolu, S.
dc.contributor.authorArslanoğlu, I.
dc.contributor.authorDöğer, E.
dc.contributor.authorYılmaz, A. A.
dc.contributor.authorUçaktürk, A.
dc.contributor.authorKarabulut, G. S.
dc.contributor.authorTuhan, H. U.
dc.contributor.authorDemir, K.
dc.contributor.authorErdeve, S. S.
dc.contributor.authorAycan, Z.
dc.contributor.authorNalbantoğlu, O.
dc.contributor.authorKara, C.
dc.contributor.authorGüngör, N.
dc.contributor.authorDarendeliler, Feyza
dc.contributor.authorBundak, Rüveyde
dc.contributor.authorAnık, Ahmet
dc.contributor.authorUçar, Ahmet
dc.contributor.authorÇayır, Atilla
dc.contributor.authorErgür, Ayça Törel
dc.contributor.authorÖzcabi, Bahar
dc.contributor.authorHaliloğlu, Belma
dc.contributor.authorÖzkan, Behzat
dc.contributor.authorEklioğlu, Beray Selver
dc.contributor.authorKirel, Birgül
dc.contributor.authorBezen, Digdem
dc.contributor.authorVurallı, Doğus
dc.contributor.authorÜnal, Edip)
dc.contributor.authorSağsak, Elif
dc.contributor.authorBugrul, Fuat
dc.contributor.authorÇatlı, Gönül
dc.contributor.authorKorkmaz, Hüseyin Anıl
dc.contributor.authorÖzbek, Mehmet Nuri
dc.contributor.authorTayfun, Meltem
dc.contributor.authorGenens, Mikayir
dc.contributor.authorBüyük, Muammer
dc.contributor.authorHatipoğllu, Nihal
dc.contributor.authorAbalı, Saygın
dc.contributor.authorKiremitçi, Seniha
dc.contributor.authorCurek, Yusuf
dc.contributor.authorSiklar, Zeynep
dc.contributor.authorAkçay, Teoman
dc.date.accessioned2020-08-30T20:06:33Z
dc.date.available2020-08-30T20:06:33Z
dc.date.issued2019
dc.departmentİstinye Üniversitesi, Hastaneen_US
dc.description.abstractAims To describe the baseline clinical and laboratory findings and treatment modalities of 367 children and adolescents diagnosed with Type 2 diabetes in various paediatric endocrinology centres in Turkey. Methods A standard questionnaire regarding clinical and laboratory characteristics at onset was uploaded to an online national database system. Data for 367 children (aged 6-18 years) newly diagnosed with Type 2 diabetes at 37 different paediatric endocrinology centres were analysed. Results After exclusion of the children with a BMI Z-score < 1 SD, those with genetic syndromes associated with Type 2 diabetes, and those whose C-peptide and/or insulin levels were not available, 227 cases were included in the study. Mean age was 13.8 +/- 2.2 (range 6.5-17.8) years, with female preponderance (68%). Family history of Type 2 diabetes was positive in 86% of the children. The mean BMI was 31.3 +/- 6.5 kg/m(2) (range 18.7-61) and BMI Z-score was 2.4 +/- 0.8 (range 1-5). More than half (57%) of the children were identified by an opportunistic diabetes screening due to existing risk markers without typical symptoms of diabetes. Only 13% (n = 29) were treated solely by lifestyle modification, while 40.5% (n = 92) were treated with metformin, 13% (n = 30) were treated with insulin, and 33.5% (n = 76) were treated with a combination of insulin and metformin initially. Mean HbA(1C) levels of the insulin and combination of insulin and metformin groups were 98 (11.1%) and 102 mmol/mol (11.5%), respectively, and also were significantly higher than the lifestyle modification only and metformin groups mean HbA(1C) levels (70(8.6%) and 67 mmol/mol (8.3%), respectively). Conclusions An opportunistic screening of children who are at high risk of Type 2 diabetes is essential, as our data showed that > 50% of the children were asymptomatic at diagnosis. The other important result of our study was the high rate of exclusion from the initial registration (38%), suggesting that accurate diagnosis of Type 2 diabetes in youth is still problematic, even for paediatric endocrinologists.en_US
dc.identifier.citationHatun, S., Yesiltepe Mutlu, G., Cinaz, P., Turan, S. U. L. T. A. N., Ekberzade, A., Bereket, A. B. D. U. L. L. A. H., ... & Arslanoglu, I. (2019). Characteristics of Turkish children with Type 2 diabetes at onset: a multicentre, cross‐sectional study. Diabetic Medicine, 36(10), 1243-1250.en_US
dc.identifier.doi10.1111/dme.14038en_US
dc.identifier.endpage1250en_US
dc.identifier.issn0742-3071en_US
dc.identifier.issn1464-5491en_US
dc.identifier.issue10en_US
dc.identifier.pmid31099079en_US
dc.identifier.scopus2-s2.0-85068536497en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1243en_US
dc.identifier.urihttps://doi.org/10.1111/dme.14038
dc.identifier.urihttps://hdl.handle.net/20.500.12713/553
dc.identifier.volume36en_US
dc.identifier.wosWOS:000487006600007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAkçay, Teomanen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofDiabetic Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleCharacteristics of Turkish children with Type 2 diabetes at onset: a multicentre, cross-sectional studyen_US
dc.typeArticleen_US

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